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AGRN — RAC1

Text-mined interactions from Literome

Weston et al., J Cell Biol 2000 : We found that agrin causes marked muscle-specific activation of Rac and Cdc42 in differentiated myotubes, as detected by biochemical measurements ... By indicating that agrin dependent activation of Rac and Cdc42 constitutes a critical step in the signaling pathway leading to AChR clustering, these findings suggest a novel role for these Rho-GTPases : the coupling of neuronal signaling to a key step in neuromuscular synaptogenesis
Lacazette et al., J Cell Biol 2003 : We show that neuronal Agrin by activating MuSK regulates the expression of musk via two pathways : the Agrin induced assembly of muscle derived neuregulin (NRG)-1/ErbB, the pathway thought to regulate acetylcholine receptor ( AChR ) expression at the synapse, and via a direct shunt involving Agrin induced activation of Rac
Nizhynska et al., Dev Neurobiol 2007 : Moreover, agrin induced activation of Rac and Cdc42 is impaired in the presence of PI3-K inhibitors ... Its role during agrin stimulated Rac and Cdc42 activation suggests a critical function during cytoskeletal reorganizations, which lead to the redistribution of actin anchored AChRs
Linnoila et al., Neuron 2008 : In cultured myotubes, Tid1 knockdown inhibited AChR clustering, as well as agrin induced activation of the Rac and Rho small GTPases and tyrosine phosphorylation of the AChR, without affecting MuSK activation
Godfrey et al., Exp Cell Res 2010 : Our results indicate that stimulation of the NO/cGMP pathway is important during the first few minutes of agrin signaling and is required for agrin induced Rac1 activation, a key step leading to reorganization of the actin cytoskeleton and subsequent aggregation of AChRs on the surface of skeletal muscle cells