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IL1A — VCAM1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VCAM1 → IL1A (increases)
  Evidence: Members of the immunoglobulin superfamily mediate heterophilic cell-cell adhesion. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are expressed on quiescent endothelium, but are upregulated after stimulation with TNF-a, IL-1 or interferon-g (IFN-g) (24).

Text-mined interactions from Literome

McHale et al., J Immunol 1999 (Lupus Nephritis) : TNF-alpha and IL-1 sequentially induce endothelial ICAM-1 and VCAM-1 expression in MRL/lpr lupus-prone mice
De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1 , IL-4, tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Orozco et al., Infect Immun 2000 (Inflammation) : Expression of VCAM-1 was mediated not only by TNF-alpha but also by IL-1alpha and IL-1beta, all of which were synthesized by endothelial cells in response to C. albicans
De Caterina et al., Arterioscler Thromb Vasc Biol 2001 : Nuclear run-on studies showed that LC IL-1alpha is necessary but not sufficient for inducing VCAM-1 gene transcription and that the combination of IFN-gamma and LC IL-1alpha is required for full VCAM-1 gene transcription
Burne et al., J Leukoc Biol 2001 (Disease Models, Animal...) : IL-1 and TNF independent pathways mediate ICAM-1/VCAM-1 up-regulation in ischemia reperfusion injury ... These data demonstrate that IL-1 and TNF are not essential for postischemic increases in ICAM-1 and VCAM-1
Harari et al., Rheumatology (Oxford) 2001 (Lupus Vulgaris) : Previously, we have shown that intercellular adhesion molecule 1 ( ICAM-1 ) and vascular cell adhesion molecule 1 ( VCAM-1 ) increase with age in a tumour necrosis factor alpha (TNF alpha)- and interleukin-1 (IL-1) dependent manner
Langley et al., Microcirculation 2001 (Melanoma...) : The enhanced expression of VCAM-1 is independent of systemic levels of TNF-alpha and IL-1alpha , but may be the result of melanoma induced alterations at the local level, as we found evidence of melanoma cell occupation in heart, brain, and liver in pulmonary metastases bearing mice
Ge et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 1999 : EGO showed significant inhibition on VCAM-1 expression induced by IL-1 alpha either in simple culture with HUVEC or in co-culture with HUVEC + U937, and could obviously down regulate the monocyte-endothelial cell adhesion under effect of IL-1 alpha
Chung et al., Yonsei Med J 2002 : This study demonstrated that UVB irradiation can alter ICAM-1 and VCAM-1 expression on the HDMEC surface and that augmentation of ICAM-1 expression and the IL-1alpha dependent induction of VCAM-1 following UVB exposure might be important steps in the pathogenesis of sunburn
Reissig et al., Eur J Nutr 2003 : IL-1alpha increased ICAM-1, VCAM-1 , and E-selectin expression compared to controls
Swerlick et al., J Immunol 1992 : IL-1 alpha also induced cell surface expression of VCAM-1 on HUVEC in a time- and dose dependent manner, but stimulation of HDMEC with IL-1 alpha at doses up to 1000 U/ml failed to induce significant cell surface expression
Teixidó et al., J Clin Invest 1992 : Consistent with this suggestion, IL-1 stimulation of stromal cells caused both increased VCAM-1 and ICAM-1 expression and increased attachment by CD34hi bone marrow cells
Zapolska-Downar et al., J Nutr Biochem 2004 : Butyrate at 10 mM/L inhibited interleukin-1 (IL-1) stimulated VCAM-1 and ICAM-1 expression
Curran et al., J Biol Chem 2005 (Astrocytoma...) : R ( + ) WIN 55,212-2 was shown to inhibit adhesion molecule and chemokine expression at the level of transcription, because it strongly inhibited the IL-1 induction of ICAM-1, VCAM-1 , and IL-8 mRNAs and blocked the IL-1 activation of their promoters
Negoro et al., Life Sci 2005 : IL-1 stimulated VCAM-1 expression by HUVEC was dose-dependently inhibited by authentic PGD ( 2 ) ... IL-1 induced increases in VCAM-1 expression in HUVEC transfected with reporter genes alone
Rassoul et al., Phytomedicine 2006 : The influence of garlic ( Allium sativum ) extract on interleukin 1alpha induced expression of endothelial intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 ... Fluorescein isothiocyanate ( FITC ) -labeled anti-ICAM-1 and FITC labeled anti-VCAM-1 were used to analyze the IL-1alpha induced expression of ICAM-1 and VCAM-1 by flow cytometry ... Incubation of HCAEC with garlic extract significantly decreased ICAM-1 and VCAM-1 expression induced by IL-1alpha
Burrows et al., Cancer Res 1991 (Melanoma) : The IL-1 present in melanoma conditioned medium induced the expression of vascular cell adhesion molecule 1 , endothelial-leukocyte adhesion molecule 1, and ICAM-1 on human umbilical vein endothelial cells ( ECs ) in culture and increased the rate at which melanoma cells and ECs adhered to each other
Bayat et al., Arterioscler Thromb Vasc Biol 2008 : Activation of thromboxane receptor upregulates interleukin (IL)-1beta induced VCAM-1 expression through JNK signaling
Gustavsson et al., Retina 2008 (Diabetes Mellitus, Experimental...) : Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ), IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes induced increased expression of caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Bayat et al., Free Radic Biol Med 2012 : Activation of TPr also enhanced IL-1ß induced vascular cell adhesion molecule (VCAM)-1 expression, but inhibited inducible nitric oxide synthase (iNOS) expression
Lehtinen et al., Cell stem cell 2012 : Cerebrospinal fluid-borne IL-1ß upregulates VCAM1 expression, which in turn regulates the architecture of the stem cell niche, redox homeostasis, and neurogenesis
Kong et al., Lipids in health and disease 2013 : However, comparing to the model rabbits, levels of TNF-a, IL-1ß and MDA decreased significantly and serum SOD activity increased , gene and protein expressions of E-sel, ICAM-1, VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol
De Caterina et al., Arterioscler Thromb 1994 (Arteriosclerosis...) : DHA, but not eicosapentaenoic acid, decreased in a dose- and time dependent fashion the expression of vascular cell adhesion molecule 1 ( VCAM-1 ) induced by interleukin (IL)-1 , tumor necrosis factor (TNF), IL-4, or bacterial lipopolysaccharide, with half-maximum inhibition at < 10 mumol/L ... In parallel with reduced surface VCAM-1 protein expression, DHA reduced VCAM-1 mRNA induction by IL-1 or TNF
De Caterina et al., J Clin Invest 1995 : In a concentration dependent manner, NO inhibited interleukin (IL)-1 alpha stimulated VCAM-1 expression by 35-55 % as determined by cell surface enzyme immunoassays and flow cytometry
Bereta et al., Cell Immunol 1993 : Flow cytometric analyses revealed that murine microvascular endothelium (MME) in culture constitutively expresses VCAM-1 and that stimulation of MME by TNF, IL-1 , or LPS, but not by PMA or staurosporine, strongly increased the surface expression of this cell adhesion molecule
Petzelbauer et al., J Immunol 1993 (Dermatitis) : Both ELAM-1 and, to a lesser extent, VCAM-1 expression are inducible by TNF, IL-1 , and/or IL-4 on capillaries and larger microvessels at 6 and 24 h ... These results with DMEC differ from human umbilical vein EC analyzed in parallel, which are completely CD36- and show transient ELAM-1 and sustained VCAM-1 expression in response to TNF and IL-1
Pang et al., Clin Exp Immunol 1994 : Finally, both LPS and IL-1 alpha up-regulated ICAM-1 and VCAM-1 gene expression
Schwachula et al., Immunobiology 1994 : The upregulation of ICAM-1 by IL-1 alpha, TNF-alpha, and IFN-gamma appeared similar, whereas the induction of VCAM-1 by IL-1 alpha , IL-4, TNF-alpha, and IFN-gamma showed differences between the three cell types
Sébire et al., Res Virol 1993 : Stimulation of microglial cells with interleukin-1 alpha and tumour necrosis factor-alpha, the main cytokines detected in HIV1 infected central nervous system ( CNS ), increased the microglial expression of alpha 1-VLA, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and beta 2-LFA-1 ( leukocyte-function associated molecule-1 ) but not of alpha L-LFA-1
Cobb et al., Eur J Immunol 1996 : In this report, we investigated the role of the proteasome complex in mediating the interleukin (IL)- 1 beta induction of VCAM-1 and ICAM-1 gene expression in human endothelial cells
Scholz et al., Transplantation 1996 (Cytomegalovirus Infections) : Whereas oxidative stress alone did not modulate any surface molecule expression, the IFN-gamma mediated expression of HLA-ABC and HLA-DR and the IL-1 mediated expression of ICAM-1, but not of ELAM-1 and VCAM-1 ( IL-1 + TNF-alpha ), was amplified
Majewska et al., Scand J Immunol 1997 : Role of tyrosine kinase enzymes in TNF-alpha and IL-1 induced expression of ICAM-1 and VCAM-1 on human umbilical vein endothelial cells ... These results demonstrate that IL-1 induced ICAM-1 and VCAM-1 expression does not result from activation of PTK dependent pathways
Hattori et al., Mol Cell Biochem 1997 : We investigated whether interleukin-1alpha (IL-1) would induce gene expression of vascular cell adhesion molecule-1 ( VCAM-1 ) in cardiac myocytes and, if so, whether nuclear factor kappaB (NF-kappaB) was involved ... IL-1 alone or together with interferon-gamma (IFN) induced VCAM-1 gene expression in the cells ... Induction of VCAM-1 gene expression in response to IL-1 and IFN was antagonized in a concentration dependent manner by pyrrolidine dithiocarbamate, an inhibitor of NF-kappa b activation ( 25-100 microM ) ... Tosyl-lysine-chloromethyl ketone, another inhibitor of NF-kappa b activation, also inhibited the expression of the VCAM-1 gene in response to IL-1 and IFN
Miller et al., J Leukoc Biol 1998 : Utilizing neutralizing antibodies, we show that CD40L mediated tissue factor and thrombomodulin modulation, as well as E-selectin and VCAM-1 upregulation, is independent of tumor necrosis factor alpha, interleukin-1alpha , or interleukin-1beta production
Chuluyan et al., Life Sci 1998 (Neuroblastoma) : VCAM-1 expression on SK-N-SH was induced by IL-1alpha and TNF alpha and IFN gamma synergized with TNF alpha in this respect on both NB cell lines