Gene interactions and pathways from curated databases and text-mining

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CASP8 — HIST2H2BE

Text-mined interactions from Literome

Zhang et al., J Invest Dermatol 2005 (Lymphoma, T-Cell, Cutaneous) : SAHA treatment caused an accumulation of acetylated histones ( H2B , H3, and H4 ), an increase of p21 ( WAF1 ) and bax proteins, a decrease of Stat6 and phospho-Stat6 proteins, and activation of caspase-3 in CTCL cells
Mani et al., Am J Physiol Heart Circ Physiol 2008 (Cardiomegaly...) : Calpeptin blocked the following PO-induced changes : calpain enrichment and activation, decreased calpastatin level, caspase-3 activation , enrichment and cleavage of gelsolin, TUNEL staining, and histone H2B phosphorylation
Lu et al., Sci China Life Sci 2010 : Full inhibition of caspase-3 activity reduced Mst1 activation and partially inhibited H2B phosphorylation ( Ser14 ), but ERK1/2, JNK1/2 and p38 activities were not affected