◀ Back to IGF1R

ANXA6 — IGF1R

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS Negatome - no physical interaction between proteins Interaction: IGF1R — ANXA6 (Absence of interaction, coimmunoprecipitation) Zhao et al., J Biol Chem 2003*

Text-mined interactions from Literome

Tsai et al., J Nutr Biochem 2011 (Neovascularization, Pathologic) : Western blotting and immunoprecipitation demonstrated that denbinobin causes more efficient inhibition of IGF-1 induced activation of IGF-1R and its downstream signaling targets, including, extracellular signal regulated kinase, Akt, mTOR, p70S6K , 4EBP and cyclin D1
Shu et al., Cellular oncology (Dordrecht) 2013 (Carcinoma, Hepatocellular...) : Klotho is a tumor suppressor that, through the regulation of IGF-1R phosphorylation and subsequent activation of downstream Akt-p70S6K and ERK signaling, regulates HCC tumor cell proliferation, apoptosis, autophagy and invasion