Schuster et al., Blood 2003
:
The effects of Bcr-Abl on C/EBP transcription-factor regulation and neutrophilic differentiation are reversed by the Abl kinase inhibitor imatinib mesylate
Christian et al., J Biol Chem 2003
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Preventing Rap activation also increased the ability of the BCR to stimulate Akt dependent phosphorylation of the FKHR transcription factor on negative regulatory sites and decreased the levels of p27Kip1, a pro-apoptotic factor whose transcription is enhanced by FKHR
Bilancio et al., Blood 2006
:
p110delta activity is indispensable for BCR induced DNA synthesis and phosphorylation of Akt/protein kinase B (PKB), forkhead transcription factor/forkhead box O3a (FOXO3a), and p70 S6 kinase (p70 S6K), with modest effects on the phosphorylation of glycogen synthase kinase 3 alpha/beta ( GSK3alpha/beta ) and extracellular signal regulated kinase ( Erk )
Stein et al., Oncogene 2011
:
Previously we have shown that the transcription factor nuclear factor-kappa B ( NF-?B ) is activated by BCR-ABL expression and is required for BCR-ABL mediated cellular transformation