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IL13 — PLA2G4A
Text-mined interactions from Literome
Rey et al., Biochim Biophys Acta 1999
:
IL-13 induces serine phosphorylation of cPLA2 in mouse peritoneal macrophages leading to arachidonic acid and PGE2 production and
blocks the zymosan induced serine phosphorylation of
cPLA2 and eicosanoid production ... Conversely, in macrophages stimulated by zymosan,
IL-13 added 30 min before zymosan
inhibited the AA release and the serine phosphorylation of
cPLA2 induced by the phagocytic agonist
Lefebvre et al., FASEB J 2010
:
As negative controls,
interleukin-8- and formyl-methionyl-leucyl-phenylalanine elicited migration in vitro was not
inhibited either by an LTB ( 4 ) receptor antagonist or by the
cPLA(2)alpha inhibitor
Chi et al., Arthritis Rheum 2011
(Arthritis, Rheumatoid) :
Cytosolic phospholipase A2 induction and prostaglandin E2 release by
interleukin-1ß via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-?B activity in human rheumatoid arthritis synovial fibroblasts
Onoe et al., J Immunol 1996
(Bone Resorption) :
A small increase ( 1.7-fold ) in
cPLA2 mRNA levels was detected in the cultures with IL-1 alpha, but the expression was not
affected by
IL-13 or IL-4
Rey et al., Biochim Biophys Acta 1998
(Inflammation) :
Indeed,
IL-13 induces a time dependent increase in the levels of
cytosolic PLA2 (cPLA2) protein and mRNA