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PDGFB — PI3

Text-mined interactions from Literome

Sachinidis et al., Br J Pharmacol 2000 : Furthermore CTX attenuated the PDGF-BB induced tyrosine phosphorylation of the PDGF-Rbeta, PI 3'-K , PLC-gamma1 and ERK1/2 indicating an action of cyclic AMP on PDGF-beta receptor
Chaudhary et al., J Cell Biochem 2001 : Akt activation by PDGF-BB was inhibited by PI 3-kinase inhibitor LY294002
Ricono et al., American journal of physiology. Renal physiology 2002 (MAP Kinase Signaling System) : PDGF AA and PDGF BB significantly increased the activities of phosphatidylinositol 3-kinase (PI 3-K) and mitogen activated protein kinase ( MAPK )
Noda et al., Invest Ophthalmol Vis Sci 2004 : PDGF-BB also activated p85 PI3-kinase , p44/p42 mitogen activated protein ( MAP ) kinase and p38 MAP kinase
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2007 : These results strongly suggest that PGF2alpha stimulated VEGF synthesis is amplified by PI3-kinase mediating PDGF-BB signaling in osteoblasts, and that the effect is exerted at a point downstream from p44/p42 MAP kinase
Razmara et al., Cell communication and signaling : CCS 2013 : Inhibition of phosphatidylinositol 3-kinase (PI3K) inhibited PDGF-BB activation of both mTORC1 and mTORC2