Gene interactions and pathways from curated databases and text-mining

◀ Back to TNF

MAP3K5 — TNF

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Liu et al., Mol Cell Biol 2000 : Activation of apoptosis signal regulating kinase 1 ( ASK1 ) by tumor necrosis factor receptor associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin
Tobiume et al., EMBO Rep 2001 : Thus, ASK1 is selectively required for TNF- and oxidative stress induced sustained activations of JNK/p38 and apoptosis
Shi et al., J Biol Chem 2003 : Tumor necrosis factor (TNF) induced activation of apoptosis signal regulating kinase 1 ( ASK1 ) and germinal center kinases ( GCKs ) and the subsequent activation of stress activated protein kinases ( SAPKs and c-Jun NH ( 2 ) -terminal kinases ) requires TNF receptor associated factor 2 (TRAF2)
Yoshizumi et al., Exp Cell Res 2004 : Ebselen inhibited TNF-alpha induced TNF receptor associated factor 2 (TRAF2)-ASK1 complex formation and phosphorylation of stress activated protein kinase ERK kinase 1 ( SEK1 ), which is an upstream signaling molecule of JNK
Zhang et al., J Biol Chem 2005 : Protein kinase D specifically mediates apoptosis signal regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor
Nakajima et al., EMBO J 2006 : Moreover, c-FLIPL directly interacts with a JNK activator, MAP kinase kinase (MKK)7, in a TNFalpha dependent manner and inhibits the interactions of MKK7 with MAP/ERK kinase kinase 1, apoptosis-signal regulating kinase 1 , and TGFbeta activated kinase 1
Wu et al., Free Radic Biol Med 2010 (Drug-Induced Liver Injury) : These studies show that TNFalpha increases oxidative stress in mice with elevated CYP2E1, with subsequent activation of ASK-1 via a mechanism involving thioredoxin-ASK-1 dissociation, followed by activation of downstream MKK and MAPK
Nishitoh et al., Mol Cell 1998 : The apoptosis signal regulating kinase 1 ( ASK1 ) is activated by TNF and stimulates JNK activation ... In untransfected mammalian cells, ASK1 rapidly associates with TRAF2 in a TNF dependent manner