◀ Back to CD8A
CD70 — CD8A
Text-mined interactions from Literome
Taraban et al., J Immunol 2004
:
Our data indicate that
CD70 expression on APCs
plays a key role in CD40 dependent
CD8 T cell responses
Yamada et al., J Immunol 2005
(Acute Disease...) :
CD70 blockade had little effect on CD4 ( + ) T cell function but
prevented CD8 ( + ) T cell mediated rejection, inhibited the proliferation and activation of effector CD8 ( + ) T cells, and diminished the expansion of effector and memory CD8 ( + ) T cells in vivo
McWilliams et al., Vaccine 2010
:
Furthermore, the
CD8 ( + ) T cell response generated by combined TLR agonist/anti-CD40 immunization is
dependent on the expression of
CD70 by DCs, as CD70 blockade following immunization dramatically decreases the CD8 T cell response
Arimoto-Miyamoto et al., Immunology 2010
:
Therefore, it is important to investigate ( i ) optimal stimuli to induce CD70 on human monocyte derived DCs ( MoDCs ), which are widely used for tumour immunotherapy, and ( ii ) the
role of
CD70 in functional differentiation of naive CD4 ( + ) and
CD8 ( + ) T cells stimulated with MoDCs
Kurche et al., J Immunol 2010
:
In contrast, the
CD8 ( + ) T cell responses to combined TLR/CD40 immunization were exclusively
dependent on
CD70 ... These requirements for CD4 ( + ) and CD8 ( + ) T cell activation were not limited to the use of combined TLR/CD40 immunization, because vaccinia virus challenge elicited primarily OX40L dependent CD4 responses and exclusively
CD70 dependent
CD8 ( + ) T cell responses
Penaloza-MacMaster et al., J Virol 2011
(Acute Disease...) :
In contrast to the reduced CD8 T cell responses after CD70 blockade during acute infection,
CD70 blockade during chronic LCMV infection
resulted in increased
CD8 T cell responses ... Our findings suggest that antigen persistence may determine the
effect of
CD27/CD70 signaling on
CD8 T cell responses
Sanchez et al., Vaccine 2012
:
We have established a vaccine model system in which the primary
CD8 ( + ) T cell response is independent of either IL-12 or type I IFN receptors, but
dependent on
CD27/CD70 interactions
Polak et al., J Invest Dermatol 2012
:
CD70-CD27 interaction
augments CD8+ T-cell activation by human epidermal Langerhans cells