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IGF1 — NFKB1
Text-mined interactions from Literome
Remacle-Bonnet et al., Cancer Res 2000
(Adenocarcinoma...) :
These findings indicate that the antiapoptotic function of
IGF-I in HT29-D4 cells is based on the enhancement of the survival pathways initiated by TNF, but not Fas, and
mediated by MAPK/p38, MAPK/ERK, and
NF-kappaB , which act in concert to suppress the proapoptotic signals
Mitsiades et al., Oncogene 2002
(Multiple Myeloma) :
In contrast, the Akt inhibitor IL-6-Hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate induced cell death of both Dex- and Doxo-sensitive and -resistant cells ; opposed the protective effect of constitutive Akt activity against Apo2L/TRAIL ; and abrogated the
NF-kappaB activation, increase of anti-apoptotic proteins and protection against Apo2L/TRAIL
induced by
IGF-1
Poulaki et al., Am J Pathol 2002
(Retinoblastoma) :
Inhibition of the p38 kinase sensitized cells to SN50 induced cell death, whereas
insulin-like growth factor-1 activated
NF-kappaB and attenuated the proapoptotic effect of SN50
Vallée et al., Biochem Biophys Res Commun 2003
(Adenocarcinoma...) :
Indeed, TNF alpha induced NF-kappa B translocation was not sufficient to support enhancement of the transcription and
des-IGF-1 did not promote but partly
inhibited both the TNF alpha induced
NF-kappa B activation and I kappa B alpha degradation through a PI-3K dependent pathway
Kim et al., Mol Cells 2003
:
IGF-1 increased the activity of signal transducer and activator of transcription 6 ( STAT6 ) in response to IL-4, and
activated NF-(kappa)B
Eichten et al., Virology 2004
:
Expression of two
insulin-like growth factor-1 binding proteins, IGFBP-2 and -5, is increased presumably in
response to enhanced
NF-kappaB activity in HPV-16 E7-expressing serum starved cells
Kim et al., Biochem Biophys Res Commun 2004
(MAP Kinase Signaling System) :
Furthermore,
IGF-II remarkably
increased the DNA binding activities of
NF-kappaB and AP-1, and the IL-8 promoter activity
Eisner et al., FEBS Lett 2006
:
Hyperosmotic stress dependent
NFkappaB activation is
regulated by reactive oxygen species and
IGF-1 in cultured cardiomyocytes ...
NFkappaB activation and procaspase-3 and -9 fragmentation were
prevented by NAC and
IGF-1 ...
IGF-1 prevents
NFkappaB activation by a ROS independent mechanism
Ren et al., J Mol Endocrinol 2007
:
Further study demonstrated that
IGF-I induced the DNA binding activity of
NF-kappaB in association with decreased expression of the NF-kappaB inhibitory protein IkappaBalpha ... Using a specific phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, we also found that PI3K was involved in the pathway by which
IGF-I activated
NF-kappaB and increased FLIP expression
Wu et al., J Biol Chem 2008
:
In rat growth plate chondrocytes,
IGF-I induced
NF-kappaB-p65 nuclear translocation ... Moreover, the inhibition of the phosphatidylinositol 3-kinase and Akt abolished the
effects of
IGF-I on
NF-kappaB activation
Ren et al., Acta Pharmacol Sin 2009
:
Further studies showed that
IGF-1 specifically
induced NF-kappaB activity
Salminen et al., Cell Signal 2010
:
We will discuss the evidence that
insulin/IGF-1 signaling can
enhance the
NF-kappaB signaling and subsequently potentiate the aging process and aggravate age related degenerative diseases