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SMAD4 — UBC

Pathways - manually collected, often from reviews:

• Reactome Reaction: SMAD4 → UBC (reaction) Bonni et al., Nat Cell Biol 2001, Dupont et al., Cell 2005, Nagano et al., J Biol Chem 2007, Levy et al., Mol Cell Biol 2007, Dupont et al., Cell 2009, Gao et al., Mol Cell 2009, Tang et al., EMBO J 2011
• Reactome Reaction: SMAD4 → UBC (indirect_complex) Gao et al., Mol Cell 2009
• Reactome Reaction: SMAD4 → UBC (direct_complex) Dupont et al., Cell 2005, Dupont et al., Cell 2009

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Lin et al., J Biol Chem 2003*
• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Xu et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Danielsen et al., Mol Cell Proteomics 2011
• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Wagner et al., Mol Cell Proteomics 2011
• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Udeshi et al., Mol Cell Proteomics 2012
• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Povlsen et al., Nat Cell Biol 2012
• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Fattet et al., J Cell Sci 2013*
• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Yang et al., Hum Mutat 2006*
• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Morén et al., J Biol Chem 2005*
• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Wan et al., Am J Pathol 2005*
• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Liang et al., Mol Cell Biol 2004*
• IRef Biogrid Interaction: UBC — SMAD4 (physical association, affinity chromatography technology) Lin et al., J Biol Chem 2003*
• IRef Intact Interaction: UBC — SMAD4 (physical association, anti tag coimmunoprecipitation) Tang et al., EMBO J 2011

Text-mined interactions from Literome

Lin et al., J Biol Chem 2003 : Concomitantly, SUMO-1 overexpression enhances and Ubc9 knockdown reduces levels of intranuclear Smad4 , growth inhibitory response, as well as transcriptional responses to TGF-beta
Shimada et al., Bone 2008 : The sumoylation assay showed that sumoylated Smad4 is present and dependent on Ubc9 in vitro, which was confirmed by pretreatment with Senp2, a SUMO-protease