◀ Back to BAX
BAX — TNFSF10
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Jia et al., Biochem Biophys Res Commun 2001
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
TRAIL did not
induce Bax expression and/or translocation from cytosol to mitochondria in the K562 cell line
Sarker et al., Oncogene 2002
(Breast Neoplasms...) :
TRAIL induced translocation of
Bax from cytosol to mitochondria, release of cytochrome c from mitochondria and activation of caspase-9 were all inhibited by PKC activation
Kim et al., Oncogene 2002
(Carcinoma, Hepatocellular...) :
TRAIL induced translocation of
Bax subsequent to the cleavage of Bid in parental cells
Siervo-Sassi et al., Cancer Lett 2003
(Ovarian Neoplasms) :
Apo2L/TRAIL induced the expression of pro-apoptotic proteins, Bad and
Bax ; downregulated the anti-apoptotic proteins, Bcl-2 and Bcl-xL ; and activated caspases-3, -7, -8, -9 and -10
Petak et al., Cell Death Differ 2003
(Rhabdomyosarcoma) :
Bcl-2 and Bcl-xL, but not DNC8, inhibited
TRAIL induced
Bax activation
Kim et al., Cancer Res 2004
:
Additional characterization revealed that hypoxia significantly inhibits
TRAIL induced translocation of
Bax from the cytosol to the mitochondria in HCT116 and A549 cells, with the concomitant inhibition of cytochrome c release from the mitochondria
Sinicrope et al., Clin Cancer Res 2004
(Colonic Neoplasms) :
Bcl-2 inhibited
TRAIL induced
Bax translocation, cytosolic release of cytochrome c and Smac/DIABLO, and the downstream cleavage of XIAP and DFF45
Izeradjene et al., Cancer Res 2005
(Colonic Neoplasms) :
Generation of ROS by CCCP was responsible for
TRAIL induced
Bax and caspase activation because scavenging ROS completely abrogated apical caspase-8 activation and further downstream events leading to cell death
Nieminen et al., EMBO J 2007
:
Our data is consistent with the model that activation of oncogenic c-Myc primes mitochondria through a mechanism involving activation of Bak and this priming enables weak
TRAIL induced caspase-8 signals to
activate Bax
Huang et al., Clin Cancer Res 2009
(Pancreatic Neoplasms) :
Obatoclax potentiated
TRAIL mediated
Bax/Bak activation and the release of mitochondrial cytochrome c, Smac, and AIF
Wang et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010
(Multiple Myeloma) :
TRAIL induced apoptosis in RPMI8226 cells, the expression level of genes bcl-2, mcl-1, CARP1, CARP2, XIAP and cFLIP decreased, while the expression level of
Bax increased, but the expression level of caspase-3 and NF-kappaB P65 ( RelA ) proteins decreased
Huang et al., Mol Cancer Ther 2010
(Carcinoma...) :
Because the BH3-only Bim protein is a potent inducer of mitochondrial apoptosis, Bim knockdown was shown to attenuate caspase-3, caspase-9 cleavage, and
Bax/Bak activation by sorafenib plus
TRAIL