Gene interactions and pathways from curated databases and text-mining

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GSR — TP53

Text-mined interactions from Literome

Merwin et al., Carcinogenesis 2002 : Highcopy expression of the GLR1 gene encoding glutathione reductase in Deltatrr1 yeast restored the GSSG : GSH ratio to wild-type levels, but did not restore p53 activity
Beltràn-Ramírez et al., Translational oncology 2010 : CAPE plus DEN diminished the expression of cytochrome involved in DEN bioactivation such as CYP2B1 as well as the expression of regulators of oxidative stress such as glutathione reductase , GST-kappa and GST-theta, and cell cycle regulators such as p53