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ABCA1 — MYLIP

Text-mined interactions from Literome

Horie et al., Proc Natl Acad Sci U S A 2010 : These data establish a critical role for miR-33 in the regulation of ABCA1 expression and HDL biogenesis in vivo ... Here, we generated mice lacking microRNA (miR)-33, encoded by an intron of the Srebp2, and showed that miR-33 repressed the expression of ATP binding cassette transporter A1 ( ABCA1 ) protein, a key regulator of HDL synthesis by mediating cholesterol efflux from cells to apolipoprotein A (apoA)-I
Ramirez et al., Arterioscler Thromb Vasc Biol 2011 : In mouse and human cells in vitro, miR-758 repressed the expression of ABCA1 , and conversely, the inhibition of this miRNA by using anti-miR-758 increased ABCA1 expression
Rottiers et al., Cold Spring Harb Symp Quant Biol 2011 (Metabolic Diseases) : Indeed, miR-33a/b control the levels of ATP binding cassette ( ABC ) transporter ABCA1 , a cholesterol efflux pump critical for high-density lipoprotein ( HDL ) synthesis and reverse cholesterol transport from peripheral tissues
Wijesekara et al., Diabetes 2012 : We examined whether miR-33a regulates ABCA1 expression in pancreatic islets, thereby affecting cholesterol accumulation and insulin secretion ... Adenoviral miR-33a overexpression in human or mouse islets reduced ABCA1 expression, decreased glucose stimulated insulin secretion, and increased cholesterol levels ... These findings confirm the critical role of ß-cell ABCA1 in islet cholesterol homeostasis and ß-cell function and highlight modulation of ß-cell miR-33a expression as a means to influence insulin secretion
Ramírez et al., Circ Res 2013 : miR-144 regulates cholesterol metabolism via suppressing ABCA1 expression and modulation of miRNAs may represent a potential therapeutical intervention for treating dyslipidemia and atherosclerotic vascular disease
Chen et al., Cell Metab 2013 : Sene et al. ( 2013 ) now demonstrate that in aged macrophages decreased ABCA1 expression, regulated by liver X receptor and miR-33 , impairs export of intracellular cholesterol, which promotes neovascular AMD