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ITGA5 — PTGS2

Text-mined interactions from Literome

Han et al., Int J Cancer 2005 (Carcinoma, Non-Small-Cell Lung...) : COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk : involvement of Sp1 and AP-1 sites ... The COX-2 inhibitors triggered the phosphorylation of extracellular signal regulated kinase ( Erk ) in a time dependent manner, and the inhibitor of Mek-1/Erk PD98095 prevented their inhibitory effects on integrin alpha5 expression ... Transient transfection assays showed that the COX-2 inhibitors affected integrin alpha5 gene transcription by acting between -92 to -41 bp of the human integrin alpha5 gene promoter ... Overall, these findings suggest that COX-2 inhibitors suppress alpha5beta1 integrin expression in NSCLC through effects on integrin alpha5 gene transcription mediated by Erk activation, increased Sp1, decreased AP-1 DNA binding and inactivation of SAPK/JNK signals
Tang et al., Mol Pharmacol 2006 : At the mechanistic level, anti-integrin alpha5beta1 and alphavbeta3 antibodies or rhodostomin, a snake venom disintegrin, attenuated the US-induced COX-2 expression