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CD28 — CD40

Text-mined interactions from Literome

Van Gool et al., Eur J Immunol 1999 : Blocking CD40 - CD154 and CD80/CD86 - CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production
Lee et al., J Interferon Cytokine Res 2000 (Breast Neoplasms) : IP-10 induction by E75 required HLA-A2 presentation and B7-CD28 interactions and was partially inhibited by blocking of CD40-CD40L interactions
Subauste et al., J Immunol 2000 : Taken together, T. gondii induced activation of human DC is associated with T cell production of IFN-gamma through CD40-CD40L dependent release of IL-12 and through CD80/CD86-CD28 and CD40-CD40L signaling that mediate IFN-gamma secretion even in the absence of bioactive IL-12
Girvin et al., J Autoimmun 2002 (Encephalomyelitis, Autoimmune, Experimental...) : Treatment of CD28-deficient mice with anti-CD40L at the time of immunization significantly reduced DTH responses and prevented the development of EAE following two immunizations, indicating a critical role for CD40/CD40L signaling in the absence of CD28
Ding et al., Shock 2004 (Sepsis) : In peritoneal cells, the expression of CD40 , CD80, and CD86 was unchanged, but their respective ligands CD40L, CD28 , and CD152 all increased in mice 24 h after CLP, although no such change was observed in splenocytes
Elias et al., J Immunol 2005 (Malaria...) : Production of IFN-gamma ; up-regulation of CD69, CD40L , CD95 ( Fas ), and CD95L ( Fas ligand ) ; and induction of apoptosis were also affected by the lack of CD28
Ohshima et al., J Immunol 1997 : Finally, IL-12 was produced as a result of T cell/DC interaction involving the CD40/CD40 ligand and CD28/B7 costimulation pathways, as revealed by the inhibitory effect of anti-CD40 ligand mAb and CTLA-4Ig
McDyer et al., J Immunol 1998 : CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28 dependent manner