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BTK — CD40

Text-mined interactions from Literome

Brunner et al., Immunobiology 2002 : We show here, that CD40 ligation leads to tyrosine phosphorylation of Btk in the human immature B cell line MHH-PREB-1 ... Even though the CD40 mediated tyrosine phosphorylation of Btk is less efficient than that mediated through the B cell receptor, CD40 stimulation results in a marked and continous activation of Btk in MHH-PREB-1 cells and, to a lesser extent, in a transient Btk activation in Daudi cells
Haxhinasto et al., J Biol Chem 2004 : These findings suggest a model in which Btk contributes to the enhancement of the CD40 response by TRAF2 in a PKD dependent manner
Ying et al., Immunobiology 2011 : CD40 stimulation alone also activates B cell linker (BLNK), Bruton tyrosine kinase (Btk) , and Vav-2 downstream of Syk, and significantly enhances BCR induced formation of complex consisting of, Vav-2, Btk, BLNK, and phospholipase C-gamma2 ( PLC-?2 ) leading to activation of extracellular signal regulated kinase ( ERK ), p38 mitogen activated protein kinase, Akt, and NF-?B required for optimal B cell activation