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CRK — PXN

Pathways - manually collected, often from reviews:

• KEGG Focal adhesion: CRK/CRKL → PXN (protein-protein, activation)
• NCI Pathway Database LPA receptor mediated events: Paxillin (PXN) → TRIP6/p130 Cas/FAK1/Paxillin complex (TRIP6-BCAR1-CRK) (modification, collaborate)
  Xu et al., J Biol Chem 2004, Lai et al., Mol Cell Biol 2005
  Evidence: assay, physical interaction
• NCI Pathway Database LPA receptor mediated events: Paxillin (PXN) → CRK (CRK) (modification, collaborate) Xu et al., J Biol Chem 2004, Lai et al., Mol Cell Biol 2005
  Evidence: assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: CRK (CRK) → Paxillin (PXN) (modification, collaborate) Zhang et al., Blood 2001, Chen et al., Blood 2008, Ganju et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: CRK (CRK) → PYK2/Paxillin/CRK complex (PTK2B-PXN-CRK) (modification, collaborate)
  Zhang et al., Blood 2001, Chen et al., Blood 2008, Ganju et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: RAP1B/GTP complex (RAP1B) → PYK2/Paxillin/CRK complex (PTK2B-PXN-CRK) (modification, activates)
  Zhang et al., Blood 2001, Chen et al., Blood 2008, Ganju et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: Paxillin (PXN) → PYK2/Paxillin/CRK complex (PTK2B-PXN-CRK) (modification, collaborate)
  Zhang et al., Blood 2001, Chen et al., Blood 2008, Ganju et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CXCR4-mediated signaling events: PYK2/Paxillin/CRK complex (PTK2B-PXN-CRK) → PYK2 (PTK2B) (modification, collaborate) Zhang et al., Blood 2001, Chen et al., Blood 2008, Ganju et al., J Biol Chem 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IGF1 pathway: Crk/p130 Cas/Paxillin/FAK1 complex (CRK-BCAR1-PXN-PTK2) → FAK (PTK2) (modification, collaborate) Casamassima et al., J Biol Chem 1998
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: Crk/p130 Cas/Paxillin/FAK1 complex (CRK-BCAR1-PXN-PTK2) → Crk/p130 Cas/Paxillin complex (CRK-BCAR1-PXN) (modification, collaborate)
  Casamassima et al., J Biol Chem 1998
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: p70S6K (RPS6KB1) → Crk/p130 Cas/Paxillin complex (CRK-BCAR1-PXN) (modification, activates)
  Casamassima et al., J Biol Chem 1998
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: FAK (PTK2) → Crk/p130 Cas/Paxillin complex (CRK-BCAR1-PXN) (modification, collaborate)
  Casamassima et al., J Biol Chem 1998
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → Crk/p130 Cas/Paxillin complex (CRK-BCAR1-PXN) (modification, activates)
  Murakami et al., Oncogene 1999
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: PI3K complex (PIK3CA-PIK3R1) → Crk/p130 Cas/Paxillin complex (CRK-BCAR1-PXN) (modification, activates)
  Murakami et al., Oncogene 1999
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1 complex (IGF1R-IGF1-IRS1) → Crk/p130 Cas/Paxillin complex (CRK-BCAR1-PXN) (modification, activates)
  Butler et al., J Biol Chem 1997, Fagerström et al., J Biol Chem 1998, Casamassima et al., J Biol Chem 1998
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: Paxillin (PXN) → CRK (CRK) (modification, collaborate) Butler et al., J Biol Chem 1997, Fagerström et al., J Biol Chem 1998, Casamassima et al., J Biol Chem 1998
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: Paxillin (PXN) → Crk/p130 Cas/Paxillin complex (CRK-BCAR1-PXN) (modification, collaborate)
  Butler et al., J Biol Chem 1997, Fagerström et al., J Biol Chem 1998, Casamassima et al., J Biol Chem 1998
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: CRK (CRK) → Crk/p130 Cas/Paxillin complex (CRK-BCAR1-PXN) (modification, collaborate)
  Butler et al., J Biol Chem 1997, Fagerström et al., J Biol Chem 1998, Casamassima et al., J Biol Chem 1998
  Evidence: assay, physical interaction
• NCI Pathway Database IGF1 pathway: p130 Cas (BCAR1) → Crk/p130 Cas/Paxillin complex (CRK-BCAR1-PXN) (modification, collaborate)
  Butler et al., J Biol Chem 1997, Fagerström et al., J Biol Chem 1998, Casamassima et al., J Biol Chem 1998
  Evidence: assay, physical interaction
• Reactome Reaction: PXN → CRK (reaction) Vallés et al., J Biol Chem 2004, Klemke et al., J Cell Biol 1998*
• Reactome Reaction: PXN → CRK (indirect_complex) Vallés et al., J Biol Chem 2004, Klemke et al., J Cell Biol 1998*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CRK — PXN (direct interaction, pull down) Angers-Loustau et al., J Cell Biol 1999*
• IRef Biogrid Interaction: CRK — PXN (physical association, affinity chromatography technology) Abassi et al., EMBO J 2002*
• IRef Hprd Interaction: PXN — CRK (in vivo) Abassi et al., EMBO J 2002*
• IRef Intact Interaction: PXN — CRK (physical association, anti bait coimmunoprecipitation) Takino et al., J Cell Sci 2003*
• IRef Ophid Interaction: PXN — CRK (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Furundzija et al., Biochem Biophys Res Commun 2010 (Atherosclerosis) : Pharmacological blocking experiments with specific inhibitors of Akt, PKC and p38 MAP-kinase revealed that IGF-1 dependent activation of focal adhesion kinase ( FAK ) and paxillin , and consecutively IGF-1 facilitated migration, required IGF-1/IGF-1R mediated PI3-kinase/PKC/p38 dependent integrin inside-out signaling
Sabe et al., J Biol Chem 1995 (Cell Transformation, Viral) : In this study, we detected co-immunoprecipitation of tyrosine phosphorylated paxillin with v-Crk in CT10 transformed chicken embryo fibroblasts ( CEF ), and demonstrated that v-Crk binding to paxillin can inhibit Csk binding to paxillin ... We therefore suggest that the competitive binding of overexpressed v-Crk affects an efficient interaction of Csk with tyrosine phosphorylated paxillin in CT10 transformed CEF