Sorriento et al., Proc Natl Acad Sci U S A 2008
:
The G-protein coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha ... To evaluate the effect of GRK5-IkappaB alpha interaction on NFkappaB signaling, we induced the overexpression and the knockdown of GRK5 in cell cultures ... Our results reveal an unexpected role for GRK5 in the regulation of NFkappaB transcription activity
Sorriento et al., Molecular cancer 2009
(Inflammation...) :
In vitro, adenovirus mediated GRK5-RH overexpression ( AdGRK5-NT ) in human tumor cells ( KAT-4 ) induces IkappaB accumulation and inhibits NFkappaB transcriptional activity leading to apoptotic events
Valanne et al., J Immunol 2010
:
Moreover, small interfering RNA silencing of the human ortholog GRK5 in HeLa cells impaired NF-kappaB reporter activity