Gene interactions and pathways from curated databases and text-mining

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ALDH3A2 — NFKB1

Text-mined interactions from Literome

Castro et al., Phytochemistry 2000 : NF-kappa B DNA binding was inhibited at micromolar concentrations by all Sls
García-Piñeres et al., Life Sci 2004 : In this contribution we analyzed the mechanism of the sesquiterpene lactone mediated inhibition using different cell systems, and showed that in all the cell lines analyzed, SLs inhibited both NF-kappaB binding and the IkappaB-kinase, but that the former played a more preponderant role in the inhibition
Hehner et al., J Biol Chem 1998 : Here we show that SLs prevented the activation of NF-kappa B by different stimuli such as phorbol esters, tumor necrosis factor-alpha, ligation of the T-cell receptor, and hydrogen peroxide in various cell types
Rüngeler et al., Planta Med 1998 : Here we show that these Sls do not influence the enzymes of the arachidonic acid pathway, but inhibit the activation of NF-kappa B