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NQO1 — TNF

Text-mined interactions from Literome

Ahn et al., J Biol Chem 2006 : Although overexpressed in tumor cells, the NQO1 has been linked with the suppression of carcinogenesis, and the effect of NQO1 on tumor necrosis factor (TNF) , a cytokine that mediates tumorigenesis through proliferation, invasion, angiogenesis, and metastasis of tumors, is currently unknown ... The purpose of our study was to determine the role of NQO1 in TNF cell signaling by using keratinocytes derived from wild-type and NQO1 gene deleted mice ... We also found that TNF activated NQO1 , and NQO1-specific small interfering RNA abolished the TNF induced NQO1 activity and NF-kappaB activation
Tanaka et al., Mol Pharmacol 2007 (Ischemia) : After reperfusion, 1 ) creatinine clearance decreased ; 2 ) HO-1 mRNA and protein expression in liver and kidney markedly increased ; 3 ) renal NAD(P)H: quinone oxidoreductase 1 mRNA expression was induced ; 4 ) serum TNFalpha levels increased ; 5 ) Nrf2 translocation into the nucleus of renal tissue increased ; and 6 ) renal and urinary 15-deoxy-Delta ( 12,14 ) -prostaglandin J2 ( 15-d-PGJ2 ) levels increased
Gharavi et al., J Pharm Sci 2007 (Carcinoma, Hepatocellular...) : Both TNF-alpha and LPS repressed the beta-naphthoflavone ( betaNF ) -mediated induction of Cyp1a1 and Nqo1 at mRNA and activity levels
Rushworth et al., J Immunol 2008 (Inflammation...) : Silencing expression of NQO1 alone, or in combination with heme oxygenase-1 (HO-1) silencing, markedly increased LPS induced TNF and IL-1beta expression ... Additionally, overexpression of NQO1 and/or HO-1 inhibited LPS induced TNF and IL-1beta expression
Hoshino et al., J Med Chem 2010 : Five resveratrol sulfate metabolites were synthesized and assessed for activities known to be mediated by resveratrol : inhibition of tumor necrosis factor (TNF) alpha induced NFkappaB activity, cylcooxygenases ( COX-1 and COX-2 ), aromatase, nitric oxide production in endotoxin stimulated macrophages, proliferation of KB or MCF7 cells, induction of quinone reductase 1 (QR1) , accumulation in the sub-G ( 1 ) phase of the cell cycle, and quenching of 2,2-diphenyl-1-picrylhydrazyl ( DPPH ) free radical