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CREB3 — JUN
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Gupta et al., J Biol Chem 1999
:
Our results demonstrated that : ( i ) PGN induced phosphorylation of the transcription factors ATF-1 and CREB; (ii) ATF-1 and CREB bound DNA as a dimer and induced transcriptional activation of a CRE reporter plasmid, which was inhibited by dominant negative CREB and ATF-1 ; ( iii ) PGN induced phosphorylation of
c-Jun , protein synthesis of JunB and c-Fos, and transcriptional activation of the AP-1 reporter plasmid, which was inhibited by dominant negative c-Fos ; and ( iv ) PGN induced activation of
CREB/ATF and AP-1 was
mediated through CD14
Jeon et al., Immunopharmacology 2000
:
Treatment of DEX to RAW 264.7 cells
induced a dose related inhibition of NF-kappaB/Rel and
AP-1 in chloramphenicol acetyltransferase activity, while neither NF-IL6 nor
CREB/ATF activation was affected by DEX
Lopez-Bergami et al., Cancer Cell 2007
(MAP Kinase Signaling System...) :
Constitutively active ERK increases
c-Jun transcription and stability, which are
mediated by
CREB and GSK3, respectively
Kim et al., Proc Natl Acad Sci U S A 2009
(Tetanus) :
In Drosophila motor neurons, induction of
AP-1 , a heterodimer of Fos and Jun,
induces cAMP- and
CREB dependent forms of presynaptic enhancement
Collins-Hicok et al., Mol Cell Biol 1994
:
Both CRE binding protein ( CREB ) and activator protein 1 (AP-1) can regulate RD, but their effects are in opposite directions ;
CREB represses and AP-1 activates RD. CREB induced repression and
AP-1 activation require distinct elements within the control region, but their binding and functions overlap at CRE-3 ...
CREB repression
blocks AP-1 activation in unstimulated cells
Yubero et al., Mol Endocrinol 1998
:
A double-point mutation in the -139/-122 element abolished both PKA- and c-Jun dependent regulation through this site, and overexpression of
CREB blocked
c-Jun repression