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SETD2 — SIRT3

Text-mined interactions from Literome

Bell et al., Oncogene 2011 (Neoplasms) : Moreover, overexpression of SirT3 inhibits stabilization of HIF-1a protein in hypoxia and attenuates increases in HIF-1a transcriptional activity
Fiaschi et al., Cancer Res 2012 (Neoplasms, Experimental...) : Metabolic reprogramming of both stromal and cancer cells was under strict control of the hypoxia-inducible factor 1 (HIF1), which drove redox- and SIRT3 dependent stabilization of HIF1 in normoxic conditions