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BNIP3 — E2F1
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Yurkova et al., Circ Res 2008
(Anoxia) :
The cell cycle factor
E2F-1 activates
Bnip3 and the intrinsic death pathway in ventricular myocytes
Shaw et al., Proc Natl Acad Sci U S A 2008
:
Conversely, in the absence of NF-kappaB, or during hypoxia when NF-kappaB abundance is reduced, basal
Bnip3 gene transcription is
activated by the unrestricted binding of
E2F-1 to the Bnip3 promoter ... Hence, by way of example, we show that the transcriptional inhibition of
E2F-1 dependent
Bnip3 expression by NF-kappaB highlights a survival pathway that overrides the E2F-1 tumor suppressor program