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PLCB2 — RAC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PLCB2 → RAC1 (directlyIncreases, RAC1 Activity, PLCB2 Activity) Illenberger et al., EMBO J 1998*
  Evidence: Neutrophils contain a soluble guanine-nucleotidebinding protein, made up of two components with molecular masses of 23 and 26 kDa, that mediates stimulation of phospholipase C-beta2 (PLCbeta2). We have identified the two components of the stimulatory heterodimer by amino acid sequencing as a Rho GTPase and the Rho guanine nucleotide dissociation inhibitor LyGDI. Using recombinant Rho GTPases and LyGDI, we demonstrate that PLCbeta2 is stimulated by guanosine 5'-O-(3-thiotriphosphate) (GTP[S])-act...

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: RAC1 — PLCB2 (direct interaction, x-ray crystallography) Jezyk et al., Nature structural & molecular biology 2006*

Text-mined interactions from Literome

Bourdon et al., Methods Enzymol 2006 : This method is readily applied to quantify activation of PLC by receptors and G proteins, and we illustrate here the selective activation of PLC-beta2 by Rac but not by Rho GTPases and the selective activation of PLC-epsilon by Rho but not Rac GTPases
Guo et al., J Biol Chem 2010 : Rac1 , which is associated with cytoskeletal pathways, can activate phospholipase Cbeta2 (PLCbeta2) to increase intracellular Ca ( 2+ ) levels
Illenberger et al., EMBO J 1998 : Cdc42Hs/Rac1 also stimulated PLCbeta2 in a system made up of purified recombinant proteins, suggesting that this function is mediated by direct protein-protein interaction