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EDN1 — EGF

Pathways - manually collected, often from reviews:

• NCI Pathway Database EGFR-dependent Endothelin signaling events: ETA receptor/Endothelin-1 complex (EDNRA-EDN1) → EGF (EGF) (modification, activates) Iwasaki et al., Endocrinology 1999, Cheng-Hsien et al., Pflugers Arch 2006*, Chen et al., Mol Pharmacol 2006*, Daub et al., Nature 1996, Iwasaki et al., J Cardiovasc Pharmacol 1998*
  Evidence: mutant phenotype, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: ETA receptor/Endothelin-1 complex (EDNRA-EDN1) → EGF/EGFR complex (EGF-EGFR) (modification, activates)
  Iwasaki et al., Endocrinology 1999, Cheng-Hsien et al., Pflugers Arch 2006*, Chen et al., Mol Pharmacol 2006*, Daub et al., Nature 1996, Iwasaki et al., J Cardiovasc Pharmacol 1998*
  Evidence: mutant phenotype, other species

Text-mined interactions from Literome

Haug et al., J Cardiovasc Pharmacol 2000 : Inhibitory effect of epidermal growth factor and hepatocyte growth factor on endothelin-1 release by rabbit proximal tubule cells
Jia et al., Zhonghua Nan Ke Xue 2008 (Prostatic Neoplasms) : To investigate the effects of the epidermal growth factor on the mRNA expression of endothelin-1 and its receptors ( ET ( A ) R, ET ( B ) R ) in hormone refractory prostate cancer ( HRPC ) PC-3 cell lines
Chahdi et al., Cell Signal 2010 : Endothelin-1 induces p66Shc activation through EGF receptor transactivation : Role of beta ( 1 ) Pix/Galpha ( i3 ) interaction
Cybulsky et al., J Am Soc Nephrol 1993 : Transforming growth factor-beta, complement C5b-9, thrombin, and phorbol myristate acetate significantly enhanced endothelin-1 peptide synthesis in glomerular epithelial cells ( 45, 15, 55, and 25 % above basal levels at 24 h, respectively ), whereas epidermal growth factor had no effect