◀ Back to MAP2K1

MAP2K1 — MYC

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: MAP2K1 — MYC (in vitro) Gupta et al., FEBS Lett 1994*
• IRef Ophid Interaction: MYC — MAP2K1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Cheng et al., J Biol Chem 1999 : Expression of c-Myc in response to colony stimulating factor-1 requires mitogen activated protein kinase kinase-1
Lefevre et al., Oncogene 2003 (Choroid Neoplasms...) : The inhibition of both Raf-1 and MEK1/2 induced a decrease in c-Myc production and downregulated c-Myc activity by preventing c-Myc phosphorylation in OCM-1 cells
Hattrup et al., Breast Cancer Res 2006 (Breast Neoplasms...) : Additional changes were seen at the protein level, such as increased expression of c-Myc , heightened phosphorylation of AKT, and decreased activation of MEK1/2 and ERK1/2
Aziz et al., Mol Cell Biol 1999 : Activation of Raf, v-Src, and MEK1 led to induced expression of c-Myc and cyclin D1