Wang et al., J Neuroimmunol 2000
:
The effects of VIP/PACAP on c-Jun and JunB expression lead to changes in the composition of the AP-l complexes, from c-Jun/Fos to JunB/Fos dimers, with a subsequent decrease in DNA binding and loss of transactivating activity
Nagashima et al., Mol Cell Endocrinol 2003
(Pituitary Neoplasms) :
Accordingly, PACAP stimulated AP-1 and CREB transcriptional activity and E ( 2 ) inhibited TRE-LUC but not CRE-LUC activation
Monaghan et al., J Neurochem 2008
(Neuroblastoma) :
PACAP-38 and forskolin stimulated the activation of extracellular signal regulated kinase ( ERK ), mitogen activated protein kinase ( MAP ; p38 MAP kinase ) and c-Jun N-terminal kinase (JNK) Schäfer et al., Eur J Biochem 1996
:
Both PACAP ( 1-27 ) -peptide and PACAP- ( 1-38 ) -peptide strongly increased the DNA binding activity of the c-fos/ c-jun heterodimer transcription factor AP-1 at 10 nM and also stimulated AP-1 transcriptional activity up to 20-fold in AR4-2J cells