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PTGS2 — RHOA

Text-mined interactions from Literome

Thomas et al., Infect Immun 2001 : Cytotoxic necrotizing factor from Escherichia coli induces RhoA dependent expression of the cyclooxygenase-2 Gene
Schmeck et al., Inflammation 2003 : Therefore, RhoA/Rac1/Cdc42 contribute to NF-kappaB dependent LPS- and TNFalpha induced expression of PGHS-2 in EC but had no effect on the activity of expressed COX-1 and COX-2
Chang et al., J Cell Biochem 2005 : Differential regulation of cyclooxygenase 2 expression by small GTPases Ras, Rac1, and RhoA ... Individual expression of constitutively active Ras, RhoA , or Rac1 was capable of stimulating COX-2 expression in NIH3T3 cells, but co-expression of constitutively active RhoA with either constitutively active Ras or Rac1 was required for full stimulation of COX-2 expression ... PD98059 only inhibited constitutively active Ras induced COX-2 expression, while SP600125 significantly inhibited both constitutively active Ras- and RhoA induced COX-2 expression ... Together, our data suggest that constitutively active oncogenic Ras and Rho coordinately stimulate COX-2 expression whereas transient activation of Ras but not RhoA or Rac1 mediates the induction of COX-2 in response to serum ... Furthermore, ERK and JNK activation are both required for serum- and oncogenic Ras mediated COX-2 expression whereas only JNK activation is required for oncogenic RhoA mediated stimulation of COX-2 expression
Chang et al., Cancer Res 2006 (Colonic Neoplasms...) : RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility ... Inhibition of COX-2 significantly reduced the levels of RhoA activity in HCA-7 cells, suggesting that constitutive expression of COX-2 stimulates RhoA activity