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JAK2 — PTGS2

Text-mined interactions from Literome

Ogunwobi et al., Endocrinology 2006 (Adenocarcinoma...) : We conclude that leptin stimulates cell proliferation and inhibits apoptosis in OAC cells via ERK, p38 MAPK, phosphatidylinositol 3'-kinase/Akt, and JAK2 dependent activation of COX-2 and PGE2 production
Tsoyi et al., Cell Signal 2008 : However, AG490, a specific JAK-2/STAT-1 inhibitor, efficiently prevented LPS mediated iNOS induction but not the induction of COX-2 , and CKD712 completely blocked STAT-1 phosphorylation by LPS, suggesting that the NF-kappaB and JAK-2/STAT-1 pathways but not the JNK pathway are important for CKD712 action
Gao et al., Cancer Sci 2009 (Endometrial Neoplasms) : Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3 , MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells
Xu et al., Cancer Lett 2013 (Stomach Neoplasms) : G17 increased COX-2 expression and cell proliferation were effectively blocked by CCK2R antagonist and inhibitors of JAK2 and PI3K