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IFNG — TNFRSF9
Text-mined interactions from Literome
Sun et al., J Immunol 2006
(Bronchial Hyperreactivity...) :
The engagement of
CD137 ( 4-1BB ), an inducible T cell costimulatory receptor and member of the TNF receptor superfamily, by agonistic Abs can promote strong tumor and viral immunity mediated by CD8 ( + ) T cells and
stimulate IFN-gamma production
Wang et al., Croat Med J 2008
(Carcinoma...) :
Furthermore, CD137L expression found on tumor cell lines was functional because the ligation of
CD137L on lung squamous carcinoma cells L78 with CD137 on T cells
induced IFN-gamma production by T cells, and ligation of CD137L on hepatocarcinoma cells HepG2.2.15 with CD137 triggered tumor cells to produce IL-8
Zhang et al., J Immunol 2010
:
In vitro
CD137 expression is
enhanced by CD40 stimulation and
IFN-gamma and is inhibited by IL-4, -10, and -21