Nonami et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
In contrast, DeltaC Spred augmented IL-3 induced cell proliferation and ERK activation
Kachroo et al., Br J Cancer 2013
(Prostatic Hyperplasia...) :
In functional assays, SPRED2 overexpression reduced ERK phosphorylation and inhibited prostate cancer cell proliferation and migration in response to different growth factors and full-media stimulation ( P < 0.001 )