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DUSP4 — MAPK9

Pathways - manually collected, often from reviews:

• KEGG MAPK signaling pathway: DUSP1/DUSP10/DUSP14/DUSP16/DUSP2/DUSP22/DUSP3/DUSP4/DUSP5/DUSP6/DUSP7/DUSP8/DUSP9 → MAPK10/MAPK8/MAPK9 (protein-protein, inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: DUSP4 — MAPK9 (in vivo) Chu et al., J Biol Chem 1996*
• IRef Intact Interaction: DUSP4 — MAPK9 (genetic interaction, genetic interference) Chu et al., J Biol Chem 1996*

Text-mined interactions from Literome

Givant-Horwitz et al., Gynecol Oncol 2004 (MAP Kinase Signaling System...) : The objective of the present study was to investigate the expression and clinical role of dual-specificity phosphatases ( DUSP ) , inhibitors of MAPK signaling, in ovarian cancer cells at this site
Kumabe et al., Microbiol Immunol 2010 : Activation of MAPK is negatively regulated by DUSP , which dephosphorylate the phosphothreonine and phosphotyrosine residues
Auger-Messier et al., Circ Res 2013 (Cardiomyopathies...) : Although single nulls showed no molecular effects, combined disruption of Dusp1/4 promoted unrestrained p38 MAPK activity in both mouse embryonic fibroblasts and the heart, with no change in the phosphorylation of c-Jun N-terminal kinases or extracellular signal regulated kinases at baseline or with stress stimulation