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ANGPT2 — MAP2K1

Text-mined interactions from Literome

Aoki et al., Biochem J 2000 (Cardiomegaly) : Although PD98059 and dominant negative MEK1 blocked Ang II-induced activation of the ANF promoter, SB203580 or dominant negative MEK kinase 1 (MEKK1) showed no effect
Li et al., J Appl Physiol 2004 (Anoxia) : ANG II-induced PN expression was blocked by the AT(1)-receptor antagonist losartan and by inhibitors of PI3K and MEK1/2
Zhang et al., Arterioscler Thromb Vasc Biol 2005 (Vasculitis) : Signaling distal to MEK1 involved extracellular signal regulated kinase ( ERK ) because inhibition of MEK1 suppressed the Ang II-induced activation of ribosomal S6 kinase ( RSK ), a substrate of ERK
Shimizu et al., FASEB J 2008 (Osteoporosis) : Of importance, Ang II significantly induced the expression of receptor activator of NF-kappaB ligand ( RANKL ) in osteoblasts, leading to the activation of osteoclasts, whereas these effects were completely blocked by an Ang II type 1 receptor blockade ( olmesartan ) and mitogen activated protein kinase kinase inhibitors
Abe et al., Hypertens Res 2008 : DN-MEK1 markedly inhibited Ang II-induced OPN promoter activity, while neither DN-JNK nor DN-p38 MAP kinase had any effect