◀ Back to TRAF6

TAB1 — TRAF6

Pathways - manually collected, often from reviews:

• KEGG Osteoclast differentiation: TRAF2/TRAF6 → Complex of MAP3K7-TAB1-TAB2 (protein-protein, activation)
  
• KEGG Leishmaniasis: TRAF6 → Complex of MAP3K7-TAB1-TAB2 (protein-protein, activation)
  
• KEGG Toxoplasmosis: TRAF6 → Complex of MAP3K7-TAB1-TAB2 (protein-protein, activation)
  
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → UBC13/UEV1A complex (UBE2N-UBE2V1) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: UBC13/UEV1A complex (UBE2N-UBE2V1) → TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) (modification, activates)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database p38 MAPK signaling pathway: TAB family (TAB2/TAB1) → TRAF6 (TRAF6) (modification, collaborate) Wang et al., Nature 2001, Cheung et al., EMBO J 2003, Shibuya et al., Science 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database p38 MAPK signaling pathway: TRAF6 (TRAF6) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, activates)
  Wang et al., Nature 2001, Cheung et al., EMBO J 2003, Shibuya et al., Science 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Li et al., Proc Natl Acad Sci U S A 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Li et al., Proc Natl Acad Sci U S A 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Li et al., Proc Natl Acad Sci U S A 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → UBC13/UEV1A complex (UBE2N-UBE2V1) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: UBC13/UEV1A complex (UBE2N-UBE2V1) → TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) (modification, activates)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• Reactome Reaction: TAB1 → TRAF6 (reaction) Kishimoto et al., J Biol Chem 2000, Sakurai et al., FEBS Lett 2000, Takaesu et al., Mol Cell 2000, Ono et al., J Biol Chem 2001, Kanayama et al., Mol Cell 2004, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Brown et al., J Mol Biol 2005, Besse et al., J Biol Chem 2007*, Adhikari et al., Oncogene 2007, Xia et al., Nature 2009, Kulathu et al., Nature structural & molecular biology 2009*, Shibuya et al., Science 1996
• Reactome Reaction: TAB1 → TRAF6 (direct_complex)
• Reactome Reaction: TAB1 → TRAF6 (indirect_complex) Kishimoto et al., J Biol Chem 2000, Sakurai et al., FEBS Lett 2000, Takaesu et al., Mol Cell 2000, Ono et al., J Biol Chem 2001, Kanayama et al., Mol Cell 2004, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Brown et al., J Mol Biol 2005, Besse et al., J Biol Chem 2007*, Adhikari et al., Oncogene 2007, Xia et al., Nature 2009, Kulathu et al., Nature structural & molecular biology 2009*, Shibuya et al., Science 1996
• WikiPathways EBV LMP1 signaling: Complex of MAP3K7-TAB1-MAP3K3-TRAF6 → Complex of IKBKG-CHUK-IKBKB-HSP90AA1 (activation)
  
• WikiPathways EBV LMP1 signaling: Complex of MAP3K7-TAB1-MAP3K3-TRAF6 → MAPK1 (activation)
• WikiPathways EBV LMP1 signaling: Complex of MAP3K7-TAB1-MAP3K3-TRAF6 → MAPK8 (activation)
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): TRAF6 → TAB1/MAP3K7/TAB2/TAB3 (activation)
• WikiPathways TLR4 Signaling and Tolerance: TRAF6 → Complex of MAP3K7-TAB2-TAB1 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TRAF6 — TAB1 (physical association, affinity chromatography technology) Takaesu et al., Mol Cell 2000
• IRef Biogrid Interaction: TRAF6 — TAB1 (physical association, affinity chromatography technology) Ninomiya-Tsuji et al., Nature 1999*
• IRef Biogrid Interaction: TRAF6 — TAB1 (physical association, affinity chromatography technology) Walsh et al., PloS one 2008*
• Gene Ontology Complexes protein complex: protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3) Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
• IRef Hprd Interaction: Complex of MAPK14-TAB1-MAPK14-TRAF6-TRAF6-TRAF6-TAB1-MAPK14-TAB1 (in vivo) Ge et al., Science 2002*
• IRef Hprd Interaction: TRAF6 — TAB1 (in vivo) Ninomiya-Tsuji et al., Nature 1999*
• IRef Intact Interaction: Complex of TAB1-TAB2-MAP3K7-TRAF6 (association, coimmunoprecipitation) Qian et al., J Biol Chem 2001*
• IRef Intact Interaction: Complex of 21 proteins (association, anti tag coimmunoprecipitation) Goncharov et al., EMBO J 2013
• IRef Intact Interaction: Complex of MAP3K7-TAB1-TRAF6 (association, coimmunoprecipitation) Ninomiya-Tsuji et al., Nature 1999*
• IRef Ophid Interaction: TAB1 — TRAF6 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Lee et al., J Biochem Mol Biol 2002 : The AP1 activation by TRAF2, TRAF5 , and TRAF6 was also greatly suppressed by the dominant negative TAK1 ... The AP1 activation by TRAF2, TRAF5, and TRAF6 was also greatly suppressed by the dominant negative TAK1
Lamb et al., EMBO Rep 2009 (Inflammation) : Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6 mediated Lys 63 ubiquitination