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FMNL1 — RAC1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FMNL1 — RAC1 (physical association, affinity chromatography technology) Yayoshi-Yamamoto et al., Mol Cell Biol 2000*
• IRef Biogrid Interaction: FMNL1 — RAC1 (direct interaction, pull down) Yayoshi-Yamamoto et al., Mol Cell Biol 2000*
• IRef Hprd Interaction: FMNL1 — RAC1 (in vitro) Yayoshi-Yamamoto et al., Mol Cell Biol 2000*
• IRef Hprd Interaction: FMNL1 — RAC1 (in vivo) Yayoshi-Yamamoto et al., Mol Cell Biol 2000*

Text-mined interactions from Literome

Mason et al., J Biol Chem 2011 : Our data suggest srGAP2 regulates FMNL1 in two ways ; 1 ) Rac mediated activation of FMNL1 leads to the recruitment of srGAP2, which contains a Rac-specific GAP domain ; 2 ) the SH3 domain of srGAP2 binds the formin homology 1 domain of FMNL1 to inhibit FMNL1 mediated actin severing ... We propose that after Rac dependent activation of FMNL1 , srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics
Favaro et al., J Leukoc Biol 2013 (Leukemia) : FMNL1 endogenously associates with Rac1, and FMNL1 silencing resulted in an increased Rac1 activity