◀ Back to MAPK1
MAPK1 — SOS1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MAPK1
→
Complex of GRB2-SOS1
(increases, GRB2/SOS1 Activity)
Blaukat et al., J Biol Chem 1999*
Evidence: the Grb2/Sos complex connects Pyk2 to the activation of ERK, whereas adaptor proteins p130Cas and Crk link Pyk2 with the JNK pathway.
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NCI Pathway Database IL2-mediated signaling events:
Erk1-2-active (MAPK3/MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
Erk1-2-active (MAPK3/MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
Erk1-2-active (MAPK3/MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
SHP2 (PTPN11)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database VEGFR3 signaling in lymphatic endothelium:
Erk1-2 (MAPK3/MAPK1)
→
SHC/GRB2/SOS1 complex (SOS1-GRB2-SHC1)
(modification, collaborate)
Salameh et al., Blood 2005
Evidence: assay
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WikiPathways Insulin Signaling:
RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10
→
MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Weng et al., Hum Mol Genet 2001
(Breast Neoplasms) :
PTEN
inhibits insulin stimulated
MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and
IRS-1/Grb-2/Sos complex formation in a breast cancer model
Shindo et al., J Gastroenterol 2006
(Wounds and Injuries) :
( 1 )
SOS activated IkappaB-alpha, but it did not
activate ERK1/2
MAPK
Tartaglia et al., Molecular syndromology 2010
:
SHP2 ( encoded by PTPN11 ),
SOS1 , BRAF, RAF1 and MEK1 positively
contribute to
RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations ... SHP2 ( encoded by PTPN11 ),
SOS1 , BRAF, RAF1 and MEK1 positively
contribute to
RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations
Welham et al., J Biol Chem 1995
(Leukemia, Erythroblastic, Acute...) :
In lymphohemopoietic cells, IL-13, IL-4, and insulin failed to induce increased tyrosine phosphorylation of Shc, or its association with grb2, modification of
Sos1 , or
activation of erk-1 and
erk-2 mitogen activated protein kinases, suggesting that p170 mediates downstream pathways distinct from those mediated by IRS-1
Ming et al., Nature 1994
:
Activation of
p42mapk/p44mapk is
triggered by sequential activation of the GDP-GTP exchange factor
Sos , the GTP binding protein p21ras, and protein kinases p74raf and p47mek ( refs 7-10 )
Corbalan-Garcia et al., Mol Cell Biol 1996
:
Previous studies have demonstrated that growth factor induced
Sos phosphorylation occurs at the C-terminal region of the protein and is
mediated , in part, by
mitogen activated protein ( MAP ) kinase
Lopez-Ilasaca et al., Science 1997
:
The tyrosine kinase class of receptors
induces mitogen activated protein kinase ( MAPK ) activation through the sequential interaction of the signaling proteins Grb2,
Sos , Ras, Raf, and MEK
Della Rocca et al., J Biol Chem 1997
:
Erk1/2 phosphorylation in response to alpha1B-AR stimulation is also
attenuated by coexpression of N17-Ras,
SOS-Pro , or DeltaN-Raf, but not by coexpression of betaARK1ct or by pretreatment with pertussis toxin
Nimnual et al., Science 1998
:
Ras mediated activation of
DH-PH-Sos did not
require activation of
mitogen activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase