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CDK2 — PI3
Text-mined interactions from Literome
Eapen et al., Mol Cell Biol 2001
:
Notably, the
PI 3-kinase inhibitor, LY294002, completely
blocked cytokine induced
Cdk2 activation and cell growth in irradiated 32D cells but not in nonirradiated cells
Uttamsingh et al., J Biol Chem 2003
:
UR2 infected CEF grown in nonadherent conditions displayed faster cell cycle progression than the control or the UR2 mutant infected cells, and this appeared to correlate with a
PI 3-kinase dependent increase in cyclin A-associated
Cdk2 activity ... In conclusion, we have adopted an experimental system enabling us to study the signaling pathways in cells grown under anchorage independent conditions and have identified matrix independent activation of PI 3-kinase and Stat3 signaling functions, as well as the
PI 3-kinase dependent increase of cyclin A-associated
Cdk2 kinase activity, to be critical for the Ros-PTK induced anchorage independent growth