Gene interactions and pathways from curated databases and text-mining

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CASP3 — GRB10

Text-mined interactions from Literome

Jiang et al., J Virol 2011 (Herpes Simplex) : We report here that ( i ) LAT can interfere with GrB induced apoptosis in cell cultures, ( ii ) LAT can block GrB induced cleavage ( activation ) of caspase-3 both in cell culture and in a cell-free in vitro cell extract assay, and ( iii ) LAT can protect C1300 and Neuro2A cells from cytotoxic CD8 T-cell killing in vitro
Na et al., Journal of ginseng research 2012 : In this study, we evaluated the effects of G-Rb1 on the mitochondrial permeability transition ( MPT ) and caspase-3 activity of chondrocyte apoptosis induced by H2O2
Yang et al., J Biol Chem 1998 (Breast Neoplasms) : We examined this dilemma by comparing the kinetics and pattern of GrB mediated activation of the executioner caspase-7 in vitro and in vivo ... The data suggest that GrB activates caspase-3 , which then removes the propeptide of caspase-7 allowing activation by GrB