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IL10 — PRL
Text-mined interactions from Literome
Matalka et al., Cytokine 2003
:
Prolactin enhances production of interferon-gamma,
interleukin-12 , and interleukin-10, but not of tumor necrosis factor-alpha, in a stimulus-specific manner ... On the other hand, in LPS stimulated whole blood,
prolactin enhanced significantly ( p=0.027 ) the production levels of
IL-10 , but not of IFN-gamma, IL-12 p70, and TNF-alpha, in non-concentration dependent manner
Kim et al., Mol Cells 2003
:
Interleukin-10 is
up-regulated by
prolactin and serum-starvation in cultured mammary epithelial cells
Lau et al., Immunol Lett 2006
(Diabetes Mellitus, Experimental) :
Prolactin regulation of the expression of TNF-alpha, IFN-gamma and
IL-10 by splenocytes in murine multiple low dose streptozotocin diabetes
Lee et al., Cancer Res 2005
(MAP Kinase Signaling System) :
To delineate the signaling mechanism from 16-kDa PRL, we examined the
effect of 16-kDa
PRL on
interleukin IL-1beta-inducible iNOS expression, which is regulated by two parallel pathways, one involving IFN regulatory factor 1 (IRF-1) and the other nuclear factor-kappaB (NF-kappaB)
Matalka et al., Neuroimmunomodulation 2005
:
The present study showed that the stress induced and preovulatory levels of
prolactin and estradiol, respectively,
increased the production of IFN-gamma and IL-12 levels ( and
IL-10 in the case of estradiol ) in PHA + LPS stimulated whole blood, and inhibited a hydrocortisone ( 100 nmol/l ) suppressive effect on IFN-gamma, IL-12 and IL-10 productions ... In LPS stimulated whole blood, however,
prolactin enhanced only
IL-10 production levels in a non-concentration dependent manner ... Higher
prolactin levels as in pregnancy did not modulate any of the cytokines, but pregnancy estradiol concentrations only
induced higher
IL-10 levels in PHA + LPS stimulated whole blood
Yang et al., Int Immunopharmacol 2006
:
In addition,
PRL increased the expressions of IL-6,
IL-10 , IL-12 and TNF-alpha in SDCs
Bukulmez et al., BioDrugs 1997
:
In the central nervous system,
interleukin-1 (IL-1) decreases gonadotropin releasing hormone and luteinising hormone levels and
increases prolactin levels
Matsuse et al., Allergy & rhinology (Providence, R.I.) 2012
:
The
Prl did not significantly
inhibit LPS induced
IL-10 and IL-12 production in AS mice ... More importantly,
Prl significantly
increased IL-10 and IL-12 in AS mice after RSV infection