Gene interactions and pathways from curated databases and text-mining

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IL10 — PRL

Text-mined interactions from Literome

Matalka et al., Cytokine 2003 : Prolactin enhances production of interferon-gamma, interleukin-12 , and interleukin-10, but not of tumor necrosis factor-alpha, in a stimulus-specific manner ... On the other hand, in LPS stimulated whole blood, prolactin enhanced significantly ( p=0.027 ) the production levels of IL-10 , but not of IFN-gamma, IL-12 p70, and TNF-alpha, in non-concentration dependent manner
Kim et al., Mol Cells 2003 : Interleukin-10 is up-regulated by prolactin and serum-starvation in cultured mammary epithelial cells
Lau et al., Immunol Lett 2006 (Diabetes Mellitus, Experimental) : Prolactin regulation of the expression of TNF-alpha, IFN-gamma and IL-10 by splenocytes in murine multiple low dose streptozotocin diabetes
Lee et al., Cancer Res 2005 (MAP Kinase Signaling System) : To delineate the signaling mechanism from 16-kDa PRL, we examined the effect of 16-kDa PRL on interleukin IL-1beta-inducible iNOS expression, which is regulated by two parallel pathways, one involving IFN regulatory factor 1 (IRF-1) and the other nuclear factor-kappaB (NF-kappaB)
Matalka et al., Neuroimmunomodulation 2005 : The present study showed that the stress induced and preovulatory levels of prolactin and estradiol, respectively, increased the production of IFN-gamma and IL-12 levels ( and IL-10 in the case of estradiol ) in PHA + LPS stimulated whole blood, and inhibited a hydrocortisone ( 100 nmol/l ) suppressive effect on IFN-gamma, IL-12 and IL-10 productions ... In LPS stimulated whole blood, however, prolactin enhanced only IL-10 production levels in a non-concentration dependent manner ... Higher prolactin levels as in pregnancy did not modulate any of the cytokines, but pregnancy estradiol concentrations only induced higher IL-10 levels in PHA + LPS stimulated whole blood
Yang et al., Int Immunopharmacol 2006 : In addition, PRL increased the expressions of IL-6, IL-10 , IL-12 and TNF-alpha in SDCs
Bukulmez et al., BioDrugs 1997 : In the central nervous system, interleukin-1 (IL-1) decreases gonadotropin releasing hormone and luteinising hormone levels and increases prolactin levels
Matsuse et al., Allergy & rhinology (Providence, R.I.) 2012 : The Prl did not significantly inhibit LPS induced IL-10 and IL-12 production in AS mice ... More importantly, Prl significantly increased IL-10 and IL-12 in AS mice after RSV infection