◀ Back to IL10

IL10 — MMP9

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Szony et al., Mol Hum Reprod 1999 : Furthermore, IL-10 dramatically reduces the synthesis of matrix metalloproteinase (MMP)-9 and the invasivity of cytotrophoblast cells in vitro, suggesting that an autocrine regulatory role in vivo is also possible
Lim et al., Am J Respir Crit Care Med 2000 (Pulmonary Emphysema) : IL-10 increased TIMP-1 release without modifying that of MMP-9, leading to a decrease in the MMP-9 to TIMP-1 ratio
John et al., Exp Lung Res 2002 (Pneumonia, Bacterial...) : The endogenous production of IL-10 in AM of patients with sarcoidosis and the MMP downregulation by exogenous IL-10 suggest an involvement of IL-10 in MMP regulation
An et al., Zhonghua Nei Ke Za Zhi 2003 (Lung Diseases, Obstructive...) : The expression and enzymatic activity of MMP-2 and MMP-9 in lung tissue, the counts of total leukocytes and neutrophils and the level of TNFalpha in BALF were significantly elevated, but the level of IL-10 in BALF was significantly reduced in model group compared with those in control group ( P < 0.01, respectively )
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Perianayagam et al., Eur J Clin Invest 2005 (Uremia) : We hypothesized that previously reported defective synthesis of IL-10 by immunocompetent cells exposed to a uraemic milieu may be due to impaired mitochondrial membrane potential ( MMP )
Lee et al., J Periodontol 2006 (Cardiomyopathy, Hypertrophic...) : The increased activity of MMP-9 treated with P. gingivalis medium was not mediated through p38, extracellular regulated kinase (ERK), PI3K, calcineurin, and JNK signaling pathways and was not inhibited by IL-10
Giannelli et al., J Interferon Cytokine Res 2006 : In this study, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), commonly elevated in chronic C hepatitis, stimulate the production of matrix metalloprotease-9 (MMP-9) by human hepatocytes at a transcriptional and translational level, but the addition of recombinant interferon-alpha2b ( rIFN-alpha2b ) hampers this effect
Holven et al., Stroke 2006 (Atherosclerosis...) : Our main findings were : ( 1 ) hyperhomocysteinemic subjects had raised serum levels of MMP-9 and MMP-9/TIMP-1 ratio comparing healthy controls ; ( 2 ) although IL-10 markedly suppressed MMP-9 release from PBMCs in controls, no or only minor effect was seen in hyperhomocysteinemic subjects ; ( 3 ) although IL-10 enhanced TIMP-1 levels in PBMCs from both hyperhomocysteinemic and control subjects, the increase was more prominent in controls, resulting in a marked difference in IL-10 induced changes in MMP-9/TIMP-1 ratio between these 2 groups ; and ( 4 ) comparing PBMCs from controls, cells from hyperhomocysteinemic individuals had impaired IL-10 induced STAT3 phosphorylation
Hoegl et al., Respir Med 2009 (Disease Models, Animal...) : Similarly, the activation of matrix metalloproteinase (MMP)-9 in BALF was reduced dose-dependently by IL-10
Krishnamurthy et al., Circ Res 2009 (Disease Models, Animal...) : Small interfering RNA knockdown of HuR mimicked IL-10 mediated reduction in MMP-9 expression and activity in NIH3T3 cells
Hu et al., Zhonghua Xin Xue Guan Bing Za Zhi 2008 (Myocardial Infarction...) : In vivo myocardial IL-10 transfer reduced myocardial MMP and collagen expression and increasing the TIMP expression
Coussens et al., Immunology 2009 (Tuberculosis) : We therefore determined the effects of 1alpha,25 ( OH ) ( 2 ) D ( 3 ) on expression, secretion and activity of a number of MMP and TIMP in M. tuberculosis infected human leucocytes ; we also investigated the effect of 1alpha,25 ( OH ) ( 2 ) D ( 3 ) on the secretion of interleukin-10 (IL-10) and prostaglandin E ( 2 ) ( PGE ( 2 ) ), both transcriptional regulators of MMP expression
Sharma et al., Inflammopharmacology 2013 : Gemfibrozil plus metformin decrease MMP-9 , increase IL-10 and adiponectin acting as anti-atherogenic, anti-inflammatory and immunomodulatory in IR type 2 DM
Alexander et al., Curr Eye Res 1998 : A phorbol mitogen ( TPA ), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B , stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments
Stearns et al., Invasion Metastasis 1997 (Bone Neoplasms...) : IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice : IL-10 stimulation of TIMP-1 and inhibition of MMP-2/MMP-9 expression ... However IL-10 may inhibit the production of matrix metalloproteases ( MMP ) and prevent the establishment of metastasis
Wagner et al., J Neurooncol 1998 (Brain Neoplasms...) : In all but one cell line no enhancement of MMP expression by IL-10 was detected