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IL10 — IL17D

Text-mined interactions from Literome

Fitzgerald et al., Nat Immunol 2007 (Central Nervous System Diseases...) : IL-27 induced production of IL-10 was associated with less secretion of IL-17, and exogenous IL-27 reduced the severity of adoptively transferred experimental autoimmune encephalomyelitis by a mechanism dependent on IL-10 ... Our data show that IL-27 induced production of IL-10 by effector T cells contributes to the immunomodulatory function of IL-27
Batten et al., J Immunol 2008 : Cutting edge : IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells ... In this study, we demonstrate that IL-27 induces expression of the anti-inflammatory cytokine IL-10 by CD4+ and CD8+ T cells
Kalliolias et al., J Immunol 2008 : IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38 ... Strikingly, IL-27 strongly suppressed TLR induced IL-10 production in human monocytes
Spolski et al., J Immunol 2009 : Moreover, we show that IL-21 signaling is required for maximal induction of IL-10 by IL-6 or IL-27
Xu et al., J Immunol 2009 : Both c-Maf and IL-10 induction during Th17 polarization depended on Stat3, but not Stat6 or Stat1, and mechanistically differed from IL-10 regulation by Th2 or IL-27 signals ... TGFbeta was also synergistic with IL-27 to induce c-Maf, and it induced Stat1 independent IL-10 expression in contrast to IL-27 alone
Chen et al., J Leukoc Biol 2009 (Autoimmune Diseases) : The production of IL-10 in these cells requires IL-27 and TGF-beta and was regulated by several signal pathways including Notch, STAT, and NF-kappaB
Anderson et al., J Immunol 2009 (Leishmaniasis, Cutaneous) : IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection ... In the present studies, we have explored the role for IL-27 in the regulation of IL-10 from Th1 cells in leishmaniasis
Hedrich et al., Mol Immunol 2010 : Interestingly, coculture with the IL-10 inducing cytokine IL-27 lead to a site-specific reduction in methylation of the mouse but not human IL10 gene
Wang et al., Immunol Lett 2011 : In the present study, we showed that IL-27 induced IL-10 and IFN-?, but had no effect on IL-2, TNF-a and IL-4 production from human umbilical cord blood mononuclear cells ( CBMCs ) ... Moreover, the biological function of IL-10 that was induced by IL-27 mainly enhanced the expression of CD16 without influencing CD14 expression on human monocytes
Freitas do Rosário et al., J Immunol 2012 (Inflammation...) : IL-27 promotes IL-10 production by effector Th1 CD4+ T cells : a critical mechanism for protection from severe immunopathology during malaria infection ... Finally, in this model of malaria, we demonstrate that the generation of protective IL10 ( + ) IFN-? ( + ) Th1 cells is dependent on IL-27 signaling and independent of IL-21
Zhou et al., Eur J Immunol 2012 : Here, we demonstrate that IL-10 deficiency renders LPS treatment ineffective in regulating the expression of CD40, CD80, CD86, B7-H2, and B7-DC on dendritic cells (DCs) and blocks upregulation of IL-27
Guzzo et al., PloS one 2012 (HIV Infections...) : Furthermore, we observed downregulation of IL-27 induced IL-6, TNF-a, and IL-10 expression in HIV positive subjects
Perona-Wright et al., Proc Natl Acad Sci U S A 2012 (Respiratory Tract Infections) : We show in mice that the lack of IL-10 is due to a persistent loss of IL-27 responsiveness in CD8+ memory T cells, caused by down-regulation of the common cytokine receptor, glycoprotein 130
Shen et al., Scand J Rheumatol 2013 (Behcet Syndrome...) : Elevated levels of interleukin-27 and effect on production of interferon-? and interleukin-17 in patients with Behçet 's disease
Liu et al., Eur J Immunol 2013 : While STAT3 activation and the CTL survival enhancing effects can be independent of CTL IL-10 production, we show here that IL-27 induced CTL IL-10 production contributes to memory precursor cell phenotype induction, CTL memory, and tumor rejection
Iwasaki et al., Eur J Immunol 2013 : Here, we evaluated the role of Egr-2 in IL-27 induced IL-10 production ... Although IL-27 mediated IL-10 induction was dependent on both STAT1 and STAT3, only STAT3 was required for IL-27 mediated Egr-2 induction
Fitzgerald et al., J Immunol 2013 (Encephalomyelitis, Autoimmune, Experimental) : In conclusion, IFN-ß and IL-27 both induce human IL-10 , both suppress human Th17 responses, and both suppress murine EAE ... IFN-ß-driven IL-27 is responsible for the upregulation of IL-10 , but not IL-17 suppression, by IFN-ß in human PBMCs. Surprisingly, IL-10 is not required for the suppression of IL-17 by either IL-27 or IFN-ß in this model or in de novo differentiating Th17 cells, nor is IL-27 signaling required for the suppression of experimental autoimmune encephalomyelitis ( EAE ) by IFN-ß in vivo