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PIK3R1 — PTGS2
Text-mined interactions from Literome
Sheng et al., Cancer Res 2001
(MAP Kinase Signaling System) :
Inhibition of MAPK/ERK kinase activity by PD 98059 completely blocked the K-Ras mediated induction of COX-2, whereas inhibition of
PI3K/Akt/PKB activity with LY 294002 or by expressing a dominant negative Akt ( Akt-K179M ) partially
blocked the induction of
COX-2 by K-Ras
St-Germain et al., Molecular cancer 2004
(Endometrial Neoplasms) :
Inhibition of
PI 3-K with Wortmannin and LY294002 blocked IkappaB phosphorylation, reduced NF-kappaB nuclear activity,
reduced COX-2 expression and induced apoptosis
Jang et al., Biochem Biophys Res Commun 2004
:
Moreover, inhibition of
PI3K by LY294002
caused partial decrease of catalase induced COX-2 transcription and steady-state
COX-2 transcript levels, but not COX-2 mRNA stability
St-Germain et al., Int J Oncol 2004
(Endometrial Neoplasms) :
Inhibition of
PI 3-K with Wortmannin and LY294002 blocked Akt phosphorylation and
inhibited expression of
COX-2 in mutated-PTEN cells
Chang et al., Mol Pharmacol 2004
:
In this study, we explore the
role of Ras,
phosphoinositide-3-OH-kinase (PI3K) , Akt, and transcription factor nuclear factor-kappaB (NF-kappaB) in YC-1 induced
COX-2 expression in A549 cells ... A Ras inhibitor ( manumycin A ), a
PI3K inhibitor ( wortmannin ), an Akt inhibitor ( 1l-6-Hydroxymethyl-chiro-inositol2- [ ( R ) -2-O-methyl-3-O-octadecylcarbonate ] ), and an NF-kappaB inhibitor [ pyrrolidine dithiocarbamate ( PDTC ) ] all
reduced YC-1 induced
COX-2 expression ... Taken together, these results indicate that YC-1 might activate the sGC/cGMP/PKG pathway to induce Ras and
PI3K/Akt activation, which in turn initiates IKKalpha/beta and NF-kappaB activation and finally
induces COX-2 expression in A549 cells
Chen et al., Mol Biol Cell 2005
:
MG132 induced DNA binding activity of C/EBPdelta, but not C/EBPbeta was regulated by p38,
PI3K , Src, and protein kinase C. Small interfering RNA of C/EBPdelta
suppressed COX-2 expression, further strengthening the role of C/EBPdelta in COX-2 gene transcription
Callegari et al., Int J Mol Med 2006
:
The incubation with specific inhibitors of intracellular kinases showed that
PI3K is mainly
involved in the Ox-HDL3 dependent
Cox-2 induction
Pan et al., Biochem Pharmacol 2006
(Cocarcinogenesis...) :
Taken together, these results show that acacetin down
regulates inflammatory iNOS and
COX-2 gene expression in macrophages by inhibiting the activation of NF kappa B by interfering with the activation
PI3K/Akt/IKK and MAPK, suggesting that acacetin is a functionally novel agent capable of preventing inflammation associated tumorigenesis
Hwang et al., Carcinogenesis 2007
:
Taken together, 9Z,11E-CLA
inhibits NF-kappaB
driven-COX-2 expression by blocking the IKK and
PI3K-Akt signaling in TPA treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects
Cao et al., Cell Signal 2007
(MAP Kinase Signaling System...) :
We found that
PI3K inhibitor wortmannin or LY294002
blocked COX-2 expression induced by IGF-I
Song et al., Gut 2007
(Adenocarcinoma...) :
Unconjugated bile acids
induce CREB and AP-1 dependent
COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of
PI3K/AKT and ERK1/2
Pan et al., J Agric Food Chem 2008
:
Taken together, these results show that pterostilbene down
regulates inflammatory iNOS and
COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of
PI3K/Akt/IKK and MAPK
Sun et al., Toxicol Appl Pharmacol 2008
:
These data suggest a possible
role of calcium instead of
PI3K in CT-induced
COX-2 expression in cardiomyocytes
Chen et al., Mol Immunol 2009
:
PGN induced
COX-2 expression was
attenuated by a Rac1 dominant negative mutant ( RacN17 ),
PI3K inhibitors ( wortmannin and LY 294002 ), and an Akt inhibitor ( 1L-6-hydroxymethyl-chiro-inositol2- [ ( R ) -2-O-methyl-3-O-octadecylcarbonate ] )
Gao et al., Cancer Sci 2009
(Endometrial Neoplasms) :
Leptin induced functional activation of
COX-2 is JAK2/STAT3-, MAPK/ERK-, and
PI3K/AKT dependent , indicating that COX-2 may be a critical factor of endometrial carcinogenesis in obesity
Bansal et al., PloS one 2009
:
PIM2 Induced
COX-2 and MMP-9 expression in macrophages
requires PI3K and Notch1 signaling
Liao et al., Toxicol Lett 2009
:
Cholesterol-3-beta, 5-alpha, 6-beta-triol induced
PI(3)K-Akt-eNOS dependent
cyclooxygenase-2 expression in endothelial cells
Uddin et al., Int J Cancer 2010
(Ovarian Neoplasms) :
Cyclooxygenase-2 inhibition
inhibits PI3K/AKT kinase activity in epithelial ovarian cancer
Anggakusuma et al., J Dermatol Sci 2010
(Inflammation) :
These results suggest that macelignan protects skin keratinocytes from UVB induced damage and
inhibits MMP-9 and
COX-2 expression by attenuating the activation of MAPKs and
PI3K/Akt
de Oliveira et al., Journal of neuroinflammation 2012
:
Interestingly, NVP-BEZ235, a dual
PI3K/mTOR inhibitor,
enhanced COX-2 and reduced mPGES-1 immunoreactivity, albeit PGE2 and PGD2 levels were enhanced in LPS stimulated microglia ... Taken together, we demonstrate that blockade of mTOR and/or PI3K/Akt enhances prostanoid production and that
PI3K/Akt , GSK-3 and mTOR differently
regulate the expression of mPGES-1 and
COX-2 in activated primary microglia
Xu et al., Cancer Lett 2013
(Stomach Neoplasms) :
G17 increased
COX-2 expression and cell proliferation were effectively
blocked by CCK2R antagonist and inhibitors of JAK2 and
PI3K
Díaz-Muñoz et al., J Immunol 2013
:
Cyclooxygenase-2 deficiency in macrophages
leads to defective p110?
PI3K signaling and impairs cell adhesion and migration