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NFKB1 — PTEN

Text-mined interactions from Literome

Koul et al., J Biol Chem 2001 : Tumor suppressor MMAC/PTEN inhibits cytokine induced NFkappaB activation without interfering with the IkappaB degradation pathway
Mayo et al., J Biol Chem 2002 : PTEN blocks tumor necrosis factor induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit
Vasudevan et al., Mol Cell Biol 2004 : These findings indicated that NF-kappa B activation was necessary and sufficient for inhibition of PTEN expression
Agarwal et al., Oncogene 2005 (Colorectal Neoplasms...) : Inducible expression of either KD IKK alpha or WT PTEN strongly inhibits both the constitutive NF kappa B- and beta-catenin dependent promoter and endogenous gene activation
Lee et al., Leuk Res 2005 : The DMSO induced upregulation of PTEN might be mediated by NF-kappaB activation, which was evidenced by the blockage of DMSO induced PTEN upregulation with an NF-kappaB inhibitor, pyrrolidine dithiocarbamate ( PDTC )
Chandrasekar et al., Biochem Biophys Res Commun 2006 : Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NF-kappaB dependent PTEN activation
Koul et al., Biochem Biophys Res Commun 2006 (Glioma) : We found that PTEN inhibited NFkappaB activation induced by TNF
Lee et al., Exp Mol Med 2007 (Leukemia) : We conclude that TNF-alpha induces upregulation of PTEN expression through NF-kappaB activation in human leukemic cells
Tranter et al., Free Radic Biol Med 2008 (Inflammation) : This suppression of NF-kappaB reduces levels of PTEN which relieves IL-18 mediated suppression of Akt activity
Zabalgoitia et al., Free Radic Biol Med 2008 : Treatment with interleukin (IL)-18 increased NF-kappaB activation and PTEN induction , suppressed Akt activation, and stimulated EC death ... Overexpression of HO-1, treatment with HO-1 inducer hemin, or the CO donor cobalt ( III ) protoporphyrin IX all reversed IL-18 mediated NF-kappaB activation, PTEN induction , Akt suppression, and EC death ... HO-1 overexpression, HO-1 induction, or treatment with heme metabolites all reverse IL-18 mediated p38alpha MAPK and NF-kappaB activation, PTEN induction , Akt suppression, and EC death
Chandrasekar et al., J Biol Chem 2008 (Inflammation) : Treatment with IL-18 suppressed Akt phosphorylation and its associated kinase activity, induced IkappaB kinase (IKK)-NF-kappaB dependent PTEN activation, and promoted endothelial cell death
Park et al., Cancer Res 2009 (Brain Neoplasms...) : RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN
Ghosh-Choudhury et al., Cell Signal 2010 (Breast Neoplasms) : Furthermore, expression of NFkappaB p65 subunit inhibited transcription of PTEN , resulting in reduced protein expression, which leads to enhanced phosphorylation of Akt