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RELA — RHOA

Text-mined interactions from Literome

Montaner et al., J Biol Chem 1999 : Here, we demonstrate that activation of NF-kappaB by RhoA does not exclusively promote its nuclear translocation and binding to the specific kappaB sequences
Pan et al., J Biol Chem 1999 (Adenocarcinoma...) : We previously demonstrated that BK-stimulated NF-kappaB activation requires the small GTPase RhoA
Huang et al., J Biol Chem 2001 : Chemoattractant stimulated NF-kappaB activation is dependent on the low molecular weight GTPase RhoA
Shepard et al., J Biol Chem 2001 (Sarcoma, Kaposi) : Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein coupled receptor of Kaposi 's sarcoma associated herpesvirus involve G alpha(13) and RhoA
Zhao et al., Biochem J 2002 : We also demonstrate that SP rapidly activates RhoA , Rac1 and Cdc42 and that co-expression of the dominant negative mutants of RhoA, Rac1 and Cdc42 in NK-1R cDNA transfected NCM460 cells significantly inhibits SP-induced NF-kappaB dependent gene expression
Hodge et al., Cancer Res 2003 (Adenocarcinoma...) : Transfection of these highly invasive cells with dominant negative RhoA N19 or treatment with 1.0 micro g/ml RhoA inhibitor C3 exoenzyme demonstrated that RhoA activity was necessary for both NF-kappaB activity and cellular invasion of a Matrigel reconstituted basement membrane ... RhoA activity was therefore both necessary and sufficient for the elevated NF-kappaB , invasion, and motility activities of the PC-3 highly invasive cells
Wroblewski et al., J Cell Sci 2003 (Neoplasm Invasiveness) : RhoA acted through activation of both NF-kappaB and AP-1, whereas Rac activated NF-kappaB but not AP-1
Chen et al., Biochem Biophys Res Commun 2004 : GTPase RhoA is required for fMet-Leu-Phe ( fMLP ) -stimulated NF-kappaB activation in human peripheral blood monocytes ... These results indicate that fMLP stimulates three members of the Rho family of GTPases Rac1, Cdc42, and RhoA activity in monocytes, and that Rac1 and RhoA , but not Cdc42, is required for fMLP induced NF-kappaB activation
Debidda et al., J Biol Chem 2005 (Inflammation) : STAT3 was required for the RhoA induced NF-kappaB and cyclin D1 transcription and was involved in NF-kappaB nuclear translocation
Cui et al., Circ Res 2006 : Together, these data indicate a novel mechanism for Ang II-induced NF-kappaB activation in VSMCs, mediated by RhoA induced phospho-Ser536 RelA formation, IL-6 expression, and vascular inflammation
Xu et al., Arthritis Rheum 2006 (Arthritis, Rheumatoid) : This study was conducted to examine the role of RhoA in mediating the activation of NF-kappaB in tumor necrosis factor alpha (TNFalpha) stimulated rheumatoid synoviocytes, and to evaluate the modulatory effects of statins on the TNFalpha induced activation of RhoA and NF-kappaB and the secretion of proinflammatory cytokines by rheumatoid synoviocytes
Polk et al., Am J Physiol Cell Physiol 2007 (Nephritis) : RhoA regulation of NF-kappaB activation is mediated by COX-2 dependent feedback inhibition of IKK in kidney epithelial cells ... Conversely, constitutive expression of RhoA prevented NF-kappaB activation by LPS, and this effect was reversed by cotransfection with MEKK1-KD
Manukyan et al., J Immunol 2009 : Both Src family kinases and RhoA were required for NF-kappaB activation, whereas RhoA was dispensable for type I IFN generation
Fazal et al., J Biol Chem 2009 : RNA interference knockdown of cofilin-1 stabilized the actin filaments and inhibited thrombin- and RhoA induced NF-kappaB activity
Cho et al., J Cell Biochem 2009 (Breast Neoplasms...) : KiSS1 suppresses TNFalpha induced breast cancer cell invasion via an inhibition of RhoA mediated NF-kappaB activation
Ye et al., Oncogene 2010 (Bone Cysts, Aneurysmal) : TRE17 induces transcription of MMP-9 through activation of nuclear factor-kappaB (NF-kappaB) , mediated in part by the GTPase RhoA and its effector kinase, ROCK
Perona et al., Genes Dev 1997 : The human RhoA , CDC42, and Rac-1 proteins efficiently induce the transcriptional activity of nuclear factor kappaB (NF-kappaB) by a mechanism that involves phosphorylation of Ikappa Balpha and translocation of p50/p50 and p50/p65 dimers to the nucleus, but independent of the Ras GTPase and the Raf-1 kinase
Montaner et al., J Biol Chem 1998 : Finally, mutants of RhoA and Cdc42Hs, but not that of Rac1, inhibited the activation of NF-kappaB by Ost ... However, there is a link between the NF-kappaB and the c-Jun N-terminal kinase/stress activated protein kinase ( JNK/SAPK ) cascades since a dominant negative mutant of MEKK1 is able to inhibit NF-kappaB activation induced by Rac1 and Cdc42Hs proteins, but not by RhoA