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CARD11 — RELA

Text-mined interactions from Literome

Koseki et al., J Biol Chem 1999 : Point mutations in highly conserved residues in the CARD of CIPER disrupted the ability of CIPER to activate NF-kappaB and to form homodimers, indicating that the CARD is essential for NF-kappaB activation and dimerization
Bertin et al., J Biol Chem 2000 : When expressed in cells, CARD9 binds to BCL10 and activates NF-kappaB
Bertin et al., J Biol Chem 2001 : When expressed in cells, CARD11 and CARD14 activate NF-kappaB and induce the phosphorylation of BCL10 ... When expressed in cells, CARD11 and CARD14 activate NF-kappaB and induce the phosphorylation of BCL10
Gaide et al., FEBS Lett 2001 (Lymphoma) : Carma1 , a CARD containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation ... Moreover, expression of Carma1 induces phosphorylation of Bcl10 and activation of the transcription factor NF-kappaB
Wang et al., Nat Immunol 2002 : A requirement for CARMA1 in TCR induced NF-kappa B activation
Wang et al., Mol Cell Biol 2004 : Together, these results indicate that CARMA1 mediates CD3/CD28 costimulation induced NF-kappaB activation by recruiting downstream signaling components into the immunological synapse
Stilo et al., J Biol Chem 2004 : However, the biochemical mechanism by which CARMA1 regulates activation of NFkappaB remains to be determined
Hosokawa et al., Apoptosis 2005 (Lymphoma, B-Cell, Marginal Zone...) : It has also been shown that CARMA1 , a newly discovered member of the membrane associated guanylate kinase ( MAGUK ) families, is critical for antigen receptor stimulated NF-kappaB activation
Sommer et al., Immunity 2005 : PKC isoforms and CARMA1 play crucial roles in immunoreceptor dependent NF-kappaB activation ... Together, our data support a model whereby CARMA1 phosphorylation controls NF-kappaB activation by triggering a shift from an inactive to an active CARMA1 conformer
Matsumoto et al., Immunity 2005 : CARMA1 mediates T cell receptor ( TCR ) -induced NF-kappaB activation
Narayan et al., Mol Cell Biol 2006 : CARMA1 is required for Akt mediated NF-kappaB activation in T cells
Rivera et al., Trends Immunol 2006 : The CARMA1-Bcl10-Malt1 adaptor complex regulates NFkappaB activation by antigen receptors in lymphocytes
Medoff et al., J Immunol 2006 (Asthma...) : CARMA1 has been shown to be important for Ag-stimulated activation of NF-kappaB in lymphocytes in vitro and thus could be a novel therapeutic target in inflammatory diseases such as asthma
Ishiguro et al., Mol Cell Biol 2006 : Ca2+/calmodulin dependent protein kinase II is a modulator of CARMA1 mediated NF-kappaB activation ... CARMA1 and Bcl10 functionally interact and control NF-kappaB signaling downstream of the T-cell receptor ( TCR ) ... Furthermore, CaMKII enhances CARMA1 induced NF-kappaB activation ... These results provide a novel function for CaMKII in TCR signaling and CARMA1 induced NF-kappaB activation
Tanner et al., J Biol Chem 2007 : Earlier studies indicate that CARMA1 , a Caspase Recruitment Domain ( CARD ) and Membrane associated GUanylate Kinase domain ( MAGUK ) -containing scaffold protein, plays an essential role in NF-kappaB activation induced by the costimulation of T cell receptor ( TCR ) and CD28 molecules ... However, the molecular mechanism by which CARMA1 mediates TCR-CD28 costimulation induced NF-kappaB activation is not fully understood ... Disruption of the predicted structure of the Coiled-coil domain of CARMA1 impaired its oligomerization and, importantly, abrogated CARMA1 mediated NF-kappaB activation ... Together, our results demonstrate that the oligomerization of CARMA1 is required for TCR induced NF-kappaB activation
Wegener et al., Science's STKE : signal transduction knowledge environment 2007 : CARD11 ( CARMA1 ), Bcl10, and Malt1 are required for nuclear factor NF-kappaB activation in response to antigen recognition
Medeiros et al., Science 2007 : These findings provide new insights into ADAP function and the mechanism by which CARMA1 regulates NF-kappaB activation in T cells
Hara et al., Nat Immunol 2007 (Listeriosis) : The CARMA1-Bcl-10-MALT1 complex is critical for the activation of transcription factor NF-kappaB in lymphocytes but has an unclear function in myeloid cells
Fontalba et al., J Immunol 2007 (Arthritis, Rheumatoid) : Thus, CARD8 may control NF-kappaB activation through a regulatory loop
Lenz et al., Science 2008 (Lymphoma, Large B-Cell, Diffuse) : In normal B cells, antigen receptor induced NF-kappaB activation requires CARD11 , a cytoplasmic scaffolding protein
Hara et al., J Immunol 2008 : Cell type-specific regulation of ITAM mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9 ... Surprisingly, CARMA1 deficiency also abrogated P/I induced IKK activation in DCs, indicating that CARMA1 is essential for PKC mediated NF-kappaB activation in all cell types, although the PKC-CARMA1 axis is not used downstream of myeloid ITAM receptors
Takeda et al., Int Immunol 2008 : In addition, we found that Bcl10 induced NF-kappaB activation through CD28 mediated stimulation could be blocked by the dominant negative form of PKC or CARMA1
Lam et al., Proc Natl Acad Sci U S A 2008 (Lymphoma, Large B-Cell, Diffuse) : In models of physiologic NF-kappaB pathway activation by CARD11 or tumor necrosis factor-alpha, compensatory IKKalpha activity was also observed with IKKbeta inhibition
Brenner et al., Proc Natl Acad Sci U S A 2009 : Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells ... Here, we show that HPK1 mediated NF-kappaB activation is dependent on the adaptor protein CARMA1
Davis et al., Nature 2010 (Lymphoma, Large B-Cell, Diffuse) : The signalling adaptor CARD11 is required for constitutive NF-kappaB pathway activity and survival in ABC DLBCL
Lee et al., J Biol Chem 2010 : T cell receptor stimulated NF-kappaB activation requires CARMA1 and is negatively regulated by the deubiquitinase CYLD ... The NF-kappaB activation in CYLD-deficient thymocytes is independent of CARMA1 , because the NF-kappaB activation was also detected in CYLD/CARMA1 double knock-out thymocytes