Gene interactions and pathways from curated databases and text-mining

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IL6 — PITX2

Text-mined interactions from Literome

Nakayamada et al., Arthritis Res Ther 2005 (Arthritis, Rheumatoid) : 4 ) Thrombin induced the secretion of IL-6 by RA SFs, but this action was blocked by p115RGS or Galpha13
Liu et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008 : Meanwhile, RGS1 significantly up-regulated the expression of IL-6 and IL-15, down-regulated the expression of IL-10 and IL-1
Mountz et al., Discov Med 2011 (Autoimmune Diseases) : In contrast, within the GCs, interleukin-17A (IL-17A) upregulates the expression of regulators of G protein signaling (RGS) in B cells to desensitize the G protein coupled receptor ( GPCR ) signaling pathway of CXCL12 and CXCL13 chemokines