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MAPK11 — PARP1
Text-mined interactions from Literome
Mochizuki et al., Nature 1999
:
This decrease in GTP bound
Rap1 activates
ERK/MAPK
Palsson et al., J Biol Chem 2000
:
Furthermore, constitutively active
Rap1AV12 inhibited p38
MAPK activation by IL-1, consistent with Rap antagonizing Ras function
Pizon et al., Oncogene 2000
(MAP Kinase Signaling System) :
Although the
role of
Rap1A in
MAPK activation has been analysed in various cell types, the signalling pathways activated by Rap1A have not been explored in myogenic cells
Kievit et al., Mol Endocrinol 2001
(Pituitary Neoplasms) :
These findings provide evidence for a model for cAMP induced PRL transcription involving
Rap1 induced
MAPK activity leading to stimulation of the transcriptional coactivators, CBP and p300
McDermott et al., J Biol Chem 2002
:
In the same manner, the inhibitory effect of Rap on the activation of p38 by IL-1 occurred at a point downstream of MyD88, IRAK, and TRAF6, since the activation of p38
MAPK by these components was
inhibited by overexpressing active
Rap1AV12 , while neither MKK3 nor MKK6 were affected
Huang et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
Rap1 induced p38
mitogen activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex
Chen et al., Mol Microbiol 2005
(MAP Kinase Signaling System) :
The
Rap-1 inhibitor, GGTI-298,
restored MAPK activation in the presence of cAMP, further suggesting that Rap-1 is responsible for cAMP dependent MAPK inhibition
Stork et al., Blood 2005
:
Rap1 may also regulate cellular differentiation and proliferation via pathways that are distinct from those mediating adhesion, and
involve regulation of the
mitogen activated protein ( MAP ) kinase or ERK ( extracellular signal regulated kinase ) cascade
Pladzyk et al., Invest Ophthalmol Vis Sci 2006
:
Western blot analysis was performed to determine the cleavage of poly ( ADP-ribose ) polymerase (
PARP ) and the
activation of PKC and mitogen activated protein kinase (
MAPK )
Park et al., Mol Cancer Ther 2007
(Neoplasms) :
Inhibition of p38
MAPK by treatment of SB203580 or expression of dominant negative forms of p38 MAPK suppressed the combination treatment induced Bax relocalization but did not
affect PARP-1 activation
Karhoff et al., Neuroendocrinology 2007
(Digestive System Neoplasms...) :
In endocrine cells, the small G-protein
Rap1 stimulates
mitogen activated protein kinase ( MAPK ) signaling by activating B-Raf
Minato et al., Adv Immunol 2007
(Neoplasms) :
Rap1 also
regulates MAP kinase ( MAPK ) activity in a manner highly dependent on the context of cell types
Zheng et al., Diabetes 2010
(Diabetes Mellitus, Experimental...) :
Simvastatin significantly upregulated PGC-1alpha ( P < 0.01 ), subsequently decreased Deltapsim ( P < 0.05 ) and ROS generation ( P < 0.01 ),
inhibited PARP activation ( P < 0.01 ), and further reduced VEGF expression ( P < 0.01 ) and p38
MAPK activity ( P < 0.01 )
Stadtmann et al., Eur J Immunol 2011
(Peritonitis) :
Rap1a activation by CalDAG-GEFI and p38
MAPK is involved in E-selectin dependent slow leukocyte rolling ... Our data demonstrate that
Rap1a activation by p38
MAPK and CalDAG-GEFI is involved in E-selectin dependent slow rolling and leukocyte recruitment