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CASP8 — CTNNB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ling et al., Mol Pharmacol 2001
:
All our data demonstrate that the
caspase mediated cleavage of
beta-catenin , gamma-catenin, and APC protein might contribute to paclitaxel induced apoptosis
Wong et al., Eur J Pharmacol 2001
:
These data suggest that okadaic acid induced apoptosis is p38 MAPK and
caspase dependent and that proteolytic cleavage of
beta-catenin by caspases is likely to be a downstream molecular event associated with the morphological and cytoskeletal changes induced during apoptosis
Yusta et al., J Biol Chem 2002
:
We now demonstrate that GLP-2, in a cycloheximide-insensitive manner, enhanced survival in baby hamster kidney cells stably transfected with the rat GLP-2R ; reduced mitochondrial cytochrome c efflux ; and attenuated the
caspase dependent cleavage of Akt, poly ( ADP-ribose ) polymerase, and
beta-catenin following inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002
Hwang et al., Leuk Res 2002
:
Cleavage of intact
beta-catenin was completely
inhibited by
caspase selective protease inhibitors
Li et al., Biochem Pharmacol 2002
(Adenomatous Polyposis Coli...) :
Exisulind induced degradation of
beta-catenin was not
blocked by the inhibition of
caspase-3 activity and/or apoptosis, and some SW480 cells showed a reduction in beta-catenin levels before the appearance of early apoptosis indicators
Jaiswal et al., Oncogene 2002
(Colonic Neoplasms) :
Results described a
caspase-3 mediated cleavage of
beta-catenin , decreased transactivation of beta-catenin/Tcf-Lef, decreased promoter DNA binding activity of the beta-catenin/Tcf-Lef complex, and decreased levels of c-Myc protein
Wu et al., Exp Cell Res 2003
:
In addition, general
caspase inhibitors
inhibited the cleavage of
beta-catenin and poly ( ADP-ribose ) polymerase, and DNA fragmentation, whereas they did not prevent cell shape change or detachment
Cervello et al., Int J Mol Med 2004
(Carcinoma, Hepatocellular) :
Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells : Possible correlation with specific
caspase dependent cleavage of
beta-catenin and inhibition of beta-catenin mediated transactivation ... The cleavage of
beta-catenin was
inhibited by the
caspase inhibitors Z-VAD-fmk and Z-DEVD-fmk
Nakamoto et al., Int J Mol Med 2005
(Wilms Tumor) :
Recently,
caspase-3 dependent cleavage of
beta-catenin was demonstrated to occur during apoptosis
Zhang et al., Neuroreport 2008
(Brain Ischemia...) :
Inhibiting
caspase-3 activity
blocks beta-catenin degradation after focal ischemia in rat ... The
caspase 3-specific inhibitor, Z-DQMD-FMK,
attenuated beta-catenin degradation, but it did not affect phosphorylation of both beta-catenin and glycogen synthase kinase-3beta ... In conclusion,
beta-catenin degraded after stroke, and its degradation was
caspase-3 dependent
Marchong et al., PLoS Genet 2010
(Retinoblastoma) :
Activated
caspase-3 was significantly decreased and
beta-catenin expression
increased in Cdh11 knockdown experiments in vitro
Brancolini et al., J Cell Biol 1997
:
Dismantling cell-cell contacts during apoptosis is coupled to a
caspase dependent proteolytic cleavage of
beta-catenin