◀ Back to MAPK8

MAPK8 — MAPK8IP1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK8IP1 → MAPK8 (directlyIncreases, MAPK8IP1 Activity)
  Evidence: 12756254;15911620
• OpenBEL Selventa BEL large corpus: MAPK8 → MAPK8IP1 (directlyDecreases, MAPK8IP1 Activity)
  Evidence: Moreover, suppression of the JNK pathway in liver decreases wholebody insulin resistance and improves glucose tolerance in diabetic animal models (90). Furthermore, loss-of-function mutations in JNK-interacting protein 1, a negative and essential modulator of JNK (91), causes type 2 diabetes in humans (92).
• KEGG MAPK signaling pathway: MAPK8IP1/MAPK8IP2 → MAPK10/MAPK8/MAPK9 (protein-protein, binding/association)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPK8IP1 — MAPK8 (physical association, affinity chromatography technology) Blanco et al., PloS one 2008
• IRef Biogrid Interaction: MAPK8IP1 — MAPK8 (physical association, affinity chromatography technology) Cai et al., J Biol Chem 2002*
• IRef Biogrid Interaction: MAPK8IP1 — MAPK8 (physical association, affinity chromatography technology) Whitmarsh et al., Science 1998*
• IRef Biogrid Interaction: MAPK8IP1 — MAPK8 (direct interaction, unspecified method) Ho et al., J Biol Chem 2006
• IRef Biogrid Interaction: MAPK8IP1 — MAPK8 (physical association, affinity chromatography technology) Song et al., J Cell Biol 2005*
• IRef Biogrid Interaction: MAPK8IP1 — MAPK8 (colocalization, biochemical) Blanco et al., PloS one 2008
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Blanco et al., PloS one 2008
• IRef Hprd Interaction: Complex of 37 proteins (in vivo) Blanco et al., PloS one 2008
• IRef Hprd Interaction: MAPK8IP1 — MAPK8 (in vitro) Nihalani et al., J Biol Chem 2003*, Blanco et al., PloS one 2008, Whitmarsh et al., Science 1998*
• IRef Hprd Interaction: MAPK8IP1 — MAPK8 (in vivo) Nihalani et al., J Biol Chem 2003*, Blanco et al., PloS one 2008, Whitmarsh et al., Science 1998*
• IRef Innatedb Interaction: Complex of APP-MAPK8IP1-MAPK8 (unknown, -) Scheinfeld et al., J Biol Chem 2003*
• IRef Innatedb Interaction: MAPK8IP1 — MAPK8 (unknown, -) Song et al., J Cell Biol 2005*
• IRef Intact Interaction: Complex of MAPK8-MAP2K7-TAB1-MAP3K7-MAPK8IP1 (association, molecular sieving) Blanco et al., PloS one 2008
• IRef Intact Interaction: Complex of MAP3K7-MAPK8IP1-VRK2-MAPK8 (association, pull down) Blanco et al., PloS one 2008
• IRef Intact Interaction: Complex of VRK2-MAPK8IP1-MAPK8-MAP2K7-TAB1-MAP3K7 (association, molecular sieving) Blanco et al., PloS one 2008
• IRef Intact Interaction: Complex of MAPK8-VRK2-MAP3K7-TAB1-MAPK8IP1-MAP2K7 (association, molecular sieving) Blanco et al., PloS one 2008
• IRef Intact Interaction: MAPK8IP1 — MAPK8 (physical association, pull down) Santos et al., J Virol 2006*
• IRef Intact Interaction: Complex of MAPK8-MAPK8IP1-VRK2-MAPK8-VRK2-MAPK8IP1 (association, pull down) Blanco et al., PloS one 2008
• IRef Intact Interaction: Complex of MAPK8-MAPK8IP1-VRK2-VRK2-MAPK8-MAPK8IP1 (association, pull down) Blanco et al., PloS one 2008
• IRef Ophid Interaction: MAPK8IP1 — MAPK8 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005